Hydrogen sulfide attenuates cardiac hypertrophy and fibrosis induced by abdominal aortic coarctation in rats.
Hydrogen sulfide attenuates cardiac hypertrophy and fibrosis induced by abdominal aortic coarctation in rats.
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DOI：
10.3892/mmr.2012.748
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发表时间：
2012-04
影响因子：
3.4
通讯作者：
Jin H
中科院分区：
文献类型：
--
作者：
Huang J;Wang D;Zheng J;Huang X;Jin H
硫化氢（H2S）是一种内源性信号气体递质。心脏肥大常在心力衰竭过程中发生。内源性H2S是否保护心肌肥大尚不清楚。本研究旨在观察硫化氢对腹主动脉缩窄所致心肌肥厚和纤维化的影响，并探讨其作用机制。雄性SD大鼠随机分为正常组、假手术组、腹主动脉缩窄（AAC）组、依那普利组和H2S组。手术后一周，依那普利和硫氢化钠（NaHS）治疗的大鼠连续喂养28天，并处死。测定各组大鼠左心室重量指数（LVMI）、心肌细胞大小和面积、胶原体积分数（CVF）。AAC组LVMI、心肌细胞体积和面积、CVF均显著增加，H2S组则显著降低。H2S降低心脏中Ang-II的水平，但不降低血浆中Ang-II的水平。此外，H2S还提高了连接蛋白43（Cx43）的表达。我们的研究结果表明，硫化氢可以显着抑制心肌肥厚和纤维化引起的压力超载，可能是通过抑制心内血管紧张素II的活性和修改Cx43的表达。
Hydrogen sulfide (H2S) has been recently found to be an endogenous signaling gasotransmitter. Cardiac hypertrophy often develops in the course of heart failure. It is unknown whether or not endogenous H2S protects cardiac hypertrophy. This study was conducted to examine the effects of H2S on cardiac hypertrophy and fibrosis induced by abdominal aortic coarctation and to explore its mechanisms. Male Sprague-Dawley rats were randomly divided into five groups: normal, sham, abdominal aortic coarctation (AAC), AAC treated with enalapril and AAC treated with H2S. One week after surgery, enalapril and sodium hydrosulfide (NaHS)-treated rats were fed for 28 consecutive days and sacrificed. After that, the left ventricle mass index (LVMI), cardiomyocyte size and areas, collagen volume fraction (CVF) of the rats were measured. In the AAC rats, the LVMI, the cardiomyocyte size and areas, and the CVF were all markedly increased while in the H2S groups they were significantly reduced. H2S decreased the levels of Ang-II in the heart, but not in plasma. In addition, H2S also improved the expression of connexin 43 (Cx43). Our results suggest that H2S can significantly suppress cardiac hypertrophy and fibrosis induced by overloaded pressure, possibly by inhibiting the activity of intracardiac Ang-II and by modifying expression of Cx43.
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DOI：
10.1124/jpet.105.092023
发表时间：
2006-02-01
影响因子：
3.5
作者：
Bian, JS;Yong, QC;Moore, PK
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DOI：
10.1073/pnas.0705891104
发表时间：
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影响因子：
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DOI：
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影响因子：
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