Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects
Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects
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DOI：
10.1021/jf040199p
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发表时间：
2005-02-09
影响因子：
6.1
通讯作者：
Nishino, H
中科院分区：
文献类型：
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作者：
Akihisa, T;Tokuda, H;Nishino, H
从红曲霉发酵大米(红霉菌)提取物中分离得到6种氮杂环酮类化合物，即红曲菌素(1)、红花黄素(2)、红曲霉毒素(3)、红曲霉毒素(4)、红曲霉酚丁胺(5)和红曲霉毒素(6)，两种呋喃异苯二甲酸酯类化合物(黄单胞菌素A(7)和黄单胞菌素B(8))，以及两种氨基酸(+)-红曲霉发酵大米(红霉米)提取物中分离到的(+)-红曲霉酸(9)和(-)-红曲霉酸(10)，研究了它们对12-O-十四烷基酚-13-乙酸酯(TPA)诱导的小鼠炎症的抑制作用。关于TPA在Raji细胞中诱导EB病毒早期抗原(EBV-EA)，以及对一氧化氮(NO)供体(+/-)-(E)-methyl-2[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide(NOR 1)激活的影响。其中，7个化合物(1-6和10)对TPA诱导的炎症反应有抑制作用，6个化合物(1，3-5，9和10)对EBV-EA激活有较强的抑制作用。所有受试化合物对NOR-1活性均有中等程度的抑制作用。
Six azaphilones, monascin (1), ankaflavin (2), rubropunctatin (3), monascorburin (4), rubropunctamine (5), and monascorburamine (6), two furanoisophthalides, xanthomonasin A (7) and xanthomonasin B (8), and two amino acids, (+)-monascumic acid (9) and (-)-monascumic acid (10), isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice) were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, on the induction of Epstein-Barr virus early antigen (EBV-EA) by TPA in Raji cells, and on the activation of (+/-)-(E)-methyl-2[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor. Among the compounds tested, seven compounds (1-6 and 10) on TPA-induced inflammation, and six compounds (1, 3-5, 9, and 10) on EBV-EA activation, exhibited potent inhibitory effects. All of the compounds tested showed moderate inhibitory effects on NOR 1 activation.