The relationship of pain and depression to cognitive function in rheumatoid arthritis patients
The relationship of pain and depression to cognitive function in rheumatoid arthritis patients
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DOI：
10.1016/s0304-3959(01)00457-2
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发表时间：
2002-04-01
期刊：
影响因子：
7.4
通讯作者：
Park, DC
中科院分区：
文献类型：
--
作者：
Brown, SC;Glass, JM;Park, DC
本研究的目的是评估疼痛和抑郁对类风湿关节炎（RA）患者认知功能产生负面影响的假设。121名社区居住类风湿性关节炎患者（年龄34-84岁）完成了一系列认知任务和多种疼痛和抑郁测量。结构方程建模技术用于评估疼痛、抑郁和年龄对认知表现的相对贡献。在认知任务中表现不佳的人比那些在认知任务中表现良好的人报告了更多的疼痛和抑郁，而且年龄更大。此外，高度疼痛与抑郁有关。进一步的分析表明，抑郁介导了疼痛和认知之间的关系。也就是说，当抑郁症被纳入分析时，先前疼痛对认知的显著影响就不复存在了。有趣的是，即使在控制了年龄之后，抑郁仍然介导了疼痛与认知的关系。这些发现表明疼痛和抑郁对于理解类风湿性关节炎的认知功能的重要性，并可能对治疗这种疾病具有重要意义。(C) 2002国际疼痛研究协会。Elsevier Science B.V.版权所有。
The purpose of this study was to assess the hypothesis that pain and depression negatively impact the cognitive functioning of individuals with rheumatoid arthritis (RA). One hundred twenty-one community-dwelling RA patients (ages 34-84) completed a battery of cognitive tasks and multiple measures of pain and depression. Structural equation modeling techniques were used to assess the relative contributions of pain, depression, and age to cognitive performance. Individuals who performed poorly on cognitive tasks reported more pain and depression and were older than those individuals who performed well on cognitive tasks. Moreover, high levels of pain were associated with depression. Further analyses revealed that depression mediated the relationship between pain and cognition. That is, when depression was entered into the analyses, the previously significant effects of pain on cognition were no longer found. Interestingly, depression still mediated the pain-cognition relationship even after controlling for age. These findings suggest the importance of both pain and depression for understanding cognitive function in RA and may have important implications for treating this disease. (C) 2002 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.