EMAP and EMAGE - A framework for understanding spatially organized data
EMAP and EMAGE - A framework for understanding spatially organized data
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DOI：
10.1385/ni:1:4:309
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发表时间：
2003-12-01
期刊：
影响因子：
3
通讯作者：
Davidson, DR
中科院分区：
文献类型：
--
作者：
Baldock, RA;Bard, JBL;Davidson, DR
爱丁堡小鼠图谱项目（EMAP）是小鼠胚胎体积模型的一个时间序列。这些模型提供了一个无背景的空间框架，结构解释和实验数据可映射其上。这使得能够对复杂的空间模式相互之间以及相对于已知或假设的结构进行整理、比较和查询。该图谱还包括一个随时间变化的解剖学本体以及以描绘的解剖区域或组织形式存在的本体与空间模型之间的映射。这些模型为浏览和可视化复杂数据提供了一个自然的图形环境。爱丁堡小鼠图谱基因表达数据库（EMAGE）是EMAP框架的首批应用之一，它提供了一个空间映射的基因表达数据库以及相关的数据映射、提交和查询工具。在本文中，我们描述了图谱和基因表达数据库的基本原理，并对MEAP和EMAGE工具的使用进行了实用介绍，包括对全身基因表达数据采集和映射新技术的使用。
The Edinburgh Mouse Atlas Project (EMAP) is a time-series of mouse-embryo volumetric models. The models provide a context-free spatial framework onto which structural interpretations and experimental data can be mapped. This enables collation, comparison, and query of complex spatial patterns with respect to each other and with respect to, known or hypothesized structure. The atlas also includes a time-dependent anatomical ontology and mapping between the ontology and the spatial models in the form of delineated anatomical regions or tissues. The models provide a natural, graphical context for browsing and visualizing complex data. The Edinburgh Mouse Atlas Gene-Expression Database (EMAGE) is one of the first applications of the EMAP framework and provides a spatially mapped gene-expression database with associated tools for data mapping, submission, and query. In this article, we describe the underlying principles of the Atlas and the gene-expression database, and provide a practical introduction to the use of the MEAP and EMAGE tools, including use of new techniques for whole body gene-expression data capture and mapping.