Hybrid PET/MRI-based delineation of gross tumor volume in head and neck cancer and tumor parameter analysis
Hybrid PET/MRI-based delineation of gross tumor volume in head and neck cancer and tumor parameter analysis
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DOI：
10.1097/mnm.0000000000000687
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发表时间：
2017-07-01
影响因子：
1.5
通讯作者：
Guo, Qi-Yong
中科院分区：
文献类型：
--
作者：
Ma, Jie-Tao;Han, Cheng-Bo;Guo, Qi-Yong
目的精确的靶区勾画可以增加靶区肿瘤的辐射剂量，同时减少对周围正常组织的损伤。然而，目前还没有用于评价由不同成像模态测量的体积的标准。本研究的目的是评估轮廓的肿瘤体积（GTV）的PET/MRI在头颈部癌症的可行性，并定义一个自适应阈值水平（aTL）划定的生物靶体积（BTV）。患者和方法18头颈部癌症患者进行了飞行时间PET/MRI前放化疗。在MRI（GTV（MRI））、PET（GTV（维斯））和融合PET/MRI（GTV（FUS））上手动勾画原发性肿瘤和转移性淋巴结的不同GTV。基于MRI的GTV轮廓代替病理GTV。以BTV体积接近GTV体积（MRI）时，确定BTV最大标准化摄取值（SUVmax）的百分位阈值界值。
Objectives Accurate target delineation allows an increase in radiation dose to the target tumor while reducing damage to the surrounding normal tissue. However, there is currently no standard for evaluating volumes measured by different imaging modalities. The aim of this study is to evaluate the feasibility of contouring gross tumor volume (GTV) by PET/MRI in head and neck cancer, and to define an adaptive threshold level (aTL) for delineating the biological target volume (BTV).Patients and methods Eighteen head and neck cancer patients underwent time of flight PET/MRI before chemoradiotherapy. Different GTVs of primary tumors and metastatic lymph nodes were manually contoured on MRI (GTV(MRI)), PET (GTV(VIS)), and fused PET/MRI (GTV(FUS)). An MRI-based GTV contour was substituted for the pathologic GTV. The percentile threshold boundary of the maximum standardized uptake value (SUVmax) for the BTV was determined when the volume of BTV approached that of GTV(MRI).Results All GTVs were highly correlated (all Pearson's r>0.85, all P