Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement.
Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement.
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DOI：
10.1117/1.jbo.25.10.106003
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发表时间：
2020-10
影响因子：
3.5
通讯作者：
Lane P
中科院分区：
文献类型：
--
作者：
Hohert G;Myers R;Lam S;Vertikov A;Lee A;Lam S;Lane P
意义：诊断可疑肺结节需要精确收集相关活检组织进行病理学分析。使用光学相干断层扫描和自体荧光成像（OCT-AFI）来提高大型成像方法无法达到的肺部部分的诊断率，可以减少与计算机断层扫描引导活检替代方案相关的并发症。目的：OCT-AFI结合市售肺活检针的可行性已被证明可用于直径小至1.9 mm的气道穿刺部位的可视化。方法：开发了一种小型化OCT-AFI成像探针，可通过18 G活检针插入。我们提出了图像引导活检的设计考虑和程序开发。进行了离体和体内猪研究，以证明手术和器械的可行性。结果：获得离体和体内OCT AFI扫描。回撤部位区分清楚。结论：该器械在体内使用是可行的。获得的图像显示，探针可有效提供穿刺部位的结构信息，可用于在采集前评估样本的诊断潜力。
Significance: Diagnosis of suspicious lung nodules requires precise collection of relevant biopsies for histopathological analysis. Using optical coherence tomography and autofluorescence imaging (OCT-AFI) to improve diagnostic yield in parts of the lung inaccessible to larger imaging methods may allow for reducing complications related to the alternative of computed tomography-guided biopsy. Aim: Feasibility of OCT-AFI combined with a commercially available lung biopsy needle was demonstrated for visualization of needle puncture sites in airways with diameters as small as 1.9 mm. Approach: A miniaturized OCT-AFI imaging stylet was developed to be inserted through an 18G biopsy needle. We present design considerations and procedure development for image-guided biopsy. Ex vivo and in vivo porcine studies were performed to demonstrate the feasibility of the procedure and the device. Results: OCT-AFI scans were obtained ex vivo and in vivo. Discrimination of pullback site is clear. Conclusions: Use of the device is shown to be feasible in vivo. Images obtained show the stylet is effective at providing structural information at the puncture site that can be used to assess the diagnostic potential of the sample prior to collection.