Multi-institutional clinical experience with the Calypso System in localization and continuous, real-time monitoring of the prostate gland during external radiotherapy
Multi-institutional clinical experience with the Calypso System in localization and continuous, real-time monitoring of the prostate gland during external radiotherapy
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DOI：
10.1016/j.ijrobp.2006.10.026
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发表时间：
2007-03-15
影响因子：
7
通讯作者：
Levine, Lisa
中科院分区：
文献类型：
--
作者：
Kupelian, Patrick;Willoughby, Twyla;Levine, Lisa
目的：报告的临床经验与电磁治疗目标定位和连续监测系统的患者局部前列腺癌接受外照射radiotherapy.Methods和材料：Calypso系统是一个目标定位设备，连续监测的位置，三个植入的电磁应答器在10 Hz的速率。该系统在五个中心使用，在整个治疗过程中定位41名患者。将电磁定位与使用皮肤标记的设置和应答器的立体X射线定位进行比较。结果：皮肤标记与Calypso系统对齐之间的差异被发现在超过75%的片段中向量长度> 5 mm。Calypso系统和X射线定位之间的比较显示出良好的一致性。定性地，连续运动是不可预测的，从持续漂移到短暂的快速运动。在41%和15%的会话中观察到累积持续时间至少30 s的位移>= 3 mm和>= 5 mm。结论：Calypso系统是一种有效的、客观的前列腺放疗定位方法。可以在放射输送之前快速、准确和客观地进行初始治疗设置。在放射治疗递送期间前列腺运动的程度和频率可以被容易地监测并用于运动管理。(c)2007爱思唯尔公司
Purpose: To report the clinical experience with an electromagnetic treatment target positioning and continuous monitoring system in patients with localized prostate cancer receiving external beam radiotherapy.Methods and Materials: The Calypso System is a target positioning device that continuously monitors the location of three implanted electromagnetic transponders at a rate of 10 Hz. The system was used at five centers to position 41 patients over a full course of therapy. Electromagnetic positioning was compared to setup using skin marks and to stereoscopic X-ray localization of the transponders. Continuous monitoring was performed in 35 patients.Results: The difference between skin mark vs. the Calypso System alignment was found to be > 5 mm in vector length in more than 75% of fractions. Comparisons between the Calypso System and X-ray localization showed good agreement. Qualitatively, the continuous motion was unpredictable and varied from persistent drift to transient rapid movements. Displacements >= 3 and >= 5 mm for cumulative durations of at least 30 s were observed during 41% and 15% of sessions. In individual patients, the number of fractions with displacements >= 3 mm ranged from 3% to 87%; whereas the number of fractions with displacements >= 5 mm ranged from 0% to 56%.Conclusion: The Calypso System is a clinically efficient and objective localization method for positioning prostate patients undergoing radiotherapy. Initial treatment setup can be performed rapidly, accurately, and objectively before radiation delivery. The extent and frequency of prostate motion during radiotherapy delivery can be easily monitored and used for motion management. (c) 2007 Elsevier Inc.