The changing landscape of Marek's disease
The changing landscape of Marek's disease
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DOI：
10.1080/03079459808419292
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发表时间：
1998-04
期刊：
影响因子：
2.8
通讯作者：
R. Witter
中科院分区：
文献类型：
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作者：
R. Witter
马立克氏病病毒被描述为一种进化的病原体。随着病毒本身在首次分离以来的30年里发生了变化，疾病及其控制的许多其他方面也发生了变化。由病毒感染引起的疾病症状通常变得更加严重，类型更加多样，并在更广泛的宿主范围内自然发生。至少有三代不同的疫苗，以及基于遗传和管理的各种控制方法。然而，由于暴发的不可预测性以及病毒演变速度快于干预策略的趋势，家禽业和研究界都对此深表担忧。
Marek's disease virus has been described as an evolving pathogen. As the virus itself has changed in the 30 years since its first isolation, so also have many other aspects of the disease and its control. The disease syndromes induced by virus infection have become generally more acute, more varied in type and occur naturally in a wider spectrum of hosts. There have been at least three distinct generations of vaccines, and a variety of control approaches based on genetics and management. One constant, however, is the deep concern of the poultry industry and research community alike, prompted by the unpredictability of outbreaks and the tendency for the virus to evolve faster than intervention strategies.