Neuropsychological functioning in bipolar disorder and schizophrenia
Neuropsychological functioning in bipolar disorder and schizophrenia
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DOI：
10.1016/j.biopsych.2006.09.025
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发表时间：
2007-07-15
影响因子：
10.6
通讯作者：
Pearlson, Godfrey D.
中科院分区：
文献类型：
--
作者：
Schretlen, David J.;Cascella, Nicola G.;Pearlson, Godfrey D.
背景：一些双相情感障碍（BD）患者即使在病情稳定时也表现出神经心理学缺陷。然而，目前还不清楚这些是否从精神分裂症（SZ）所看到的不同的性质：我们比较了106例SZ和66例BD患者316名健康成人（NC）的认知功能障碍的性质和严重程度。所有参与者完成了一个认知电池19个单独的措施。在调整他们的测试性能的年龄，性别，种族，教育，估计发病前的智商，我们得出的回归为基础的T分数为每个措施和6个认知domain.Results：两个病人组的表现显着不如NC在大多数（BD）或所有（SZ）认知测试和域。SZ患者的效应量范围为0.37至1.32（平均值= 0.97），BD患者的效应量范围为0.23至0.87（平均值= 0.59）。这些效应量的Pearson相关系数为0.71（p <0.001）。结论：双相情感障碍患者的认知缺陷较轻，但与精神分裂症患者的认知缺陷在性质上相似。这些发现支持了这样一种观点，即精神分裂症和双相情感障碍在神经心理缺陷的性质方面比严重程度方面表现出更大的表型相似性。
Background: Some patients with bipolar disorder (BD) demonstrate neuropsychological deficits even when stable. However, it remains unclear whether these differ qualitatively from those seen in schizophrenia (SZ).Methods: We compared the nature and severity of cognitive deficits shown by 106 patients with SZ and 66 patients with BD to 316 healthy adults (NC). All participants completed a cognitive battery with 19 individual measures. After adjusting their test performance for age, sex, race, education, and estimated premorbid IQ, we derived regression-based T-scores for each measure and the six cognitive domains.Results: Both patient groups performed significantly worse than NCs on most (BD) or all (SZ) cognitive tests and domains. The resulting effect sizes ranged from .37 to 1.32 (mean = .97) across tests for SZ patients and from .23 to .87 (mean = .59) for BD patients. The Pearson correlation of these effect sizes was .71 (p < .001).Conclusions: Patients with bipolar disorder suffer from cognitive deficits that are milder but qualitatively similar to those of patients with schizophrenia. These findings support the notion that schizophrenia and bipolar disorder show greater phenotypic similarity in terms of the nature than severity of their neuropsychological deficits.