The clinical impact of photodynamic therapy in thoracic surgery
The clinical impact of photodynamic therapy in thoracic surgery
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DOI：
10.1007/s10353-010-0559-5
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发表时间：
2010-10-01
影响因子：
0.6
通讯作者：
Smolle-Juettner, F.-M.
中科院分区：
文献类型：
--
作者：
Lindenmann, J.;Matzi, V.;Smolle-Juettner, F.-M.
背景技术背景：患有恶性胸膜间皮瘤、晚期食管癌或进行性肺癌的患者，不适合切除，预后仍然很差。光动力疗法（PDT）是一种非常有效的姑息治疗这些恶性肿瘤的方法。方法：其作用机制是基于光敏剂在肿瘤细胞中选择性积累后照射恶性组织，导致局部肿瘤坏死。在食管癌和恶性支气管狭窄的情况下，PDT是在内窥镜下进行的，而在恶性胸膜间皮瘤中，腔内PDT是在去皮质后进行的。研究结果：可以实现与生活质量提高和无病生存期延长相关的腔内/胸内肿瘤的显著减少，这有助于使患者适应进一步的姑息治疗程序。结论：PDT已成为一种安全、可行和有效的方法，用于内镜下姑息晚期食管癌、恶性气管支气管狭窄以及恶性胸膜间皮瘤手术治疗的支持性治疗选择。
BACKGROUND: Patients suffering from malignant pleural mesothelioma, advanced esophageal cancer or progressive lung cancer, ineligible for resection, still have a poor prognosis. Photodynamic Therapy (PDT) is a very effective approach in the palliative treatment regimen of these malignancies. METHODS: The mechanism of function is based on the illumination of malignant tissue after selective accumulation of photosensitizers in tumor cells resulting in local tumor necrosis. In case of esophageal cancer and malignant bronchogenic stenosis, PDT is performed endoscopically whereas in malignant pleural mesothelioma intra-cavitary PDT is done after decortication. RESULTS: Significant reduction of the endoluminal/intrathoracic tumor associated with increased quality of life and prolonged disease-free survival can be achieved which helps conditioning the patient for further palliative treatment procedures. CONCLUSIONS: PDT has become a safe, feasible, and efficient approach in the endoscopic palliation of advanced esophageal cancer, malignant tracheo-bronchial stenosis as well as a supportive treatment option in the surgical management of malignant pleural mesothelioma.