Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer
Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer
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DOI：
10.1158/0008-5472.can-05-3987
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发表时间：
2006-04-15
期刊：
影响因子：
11.2
通讯作者：
Hayes, RB
中科院分区：
文献类型：
--
作者：
Michaud, DS;Daugherty, SE;Hayes, RB
慢性前列腺炎性疾病被认为在前列腺癌的发病机制中起一定作用。细胞因子基因的多态可以影响炎症和免疫反应，并可能与前列腺癌的风险有关。对503例前列腺癌患者和652例对照组进行了白细胞介素1B(IL-1B)、IL-6和IL-8基因的4个常见单核苷酸多态性(SNPs)的检测，并在817例前列腺癌患者和1190例对照组(共计1320例前列腺癌患者和1255例对照组)中检测了IL-10的3个SNPs。病例和对照是从正在进行的前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中挑选出来的，在年龄、种族、首次筛查开始的时间和抽血日期方面进行了频率匹配。单基因座分析采用条件Logistic回归分析。此外，我们还对所测试的三个IL-10单核苷酸多态进行了单倍型分析。总体而言，在这项研究中检查的四个细胞因子基因的七个多态与前列腺癌风险之间没有发现关联。使用非类固醇抗炎药的进一步分层并没有改变相关性。早期或晚期前列腺癌的研究结果与此类似。同样，我们没有观察到主要的IL-10单倍型与前列腺癌风险之间的关联。至少7种常见的炎性细胞因子IL-1B、IL-6、IL-8和IL-10基因的多态性似乎与前列腺癌的风险无关。
Chronic intraprostatic inflammation is suspected to play a role in the pathogenesis of prostate cancer. Polymorphisms in cytokine genes can influence inflammation and immune response and may be related to the risk of prostate cancer. Four common single nucleotide polymorphisms (SNPs) in the genes encoding interleukin-1B (IL-1B), IL-6, and IL-8 were assessed in 503 prostate cancer cases and 652 controls, and three SNPs in IL-10 were assessed in an additional 817 prostate cancer cases and 1,190 controls (for a total of 1,320 prostate cancer cases and 1,255 controls). Cases and controls were selected from the on-going Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial and were frequency matched on age, ethnicity, time-period since initial screening, and date of blood draw. Single-locus analyses were conducted using conditional logistic regression. In addition, we did a haplotype analysis for the three IL-10 SNPs tested. Overall, no associations were detected between the seven polymorphisms in the four cytokine genes examined in this study and prostate cancer risk. Further stratifying by use of nonsteroidal anti-inflammatory drugs did not modify the associations. Findings were similar for early or advanced prostate cancers. Similarly, we observed no association between the major IL-10 haplotypes and the risk of prostate cancer. At least seven common polymorphisms in genes of inflammatory cytokines IL-1B, IL-6, IL-8, and IL-10 do not seem to play a role in the risk of prostate cancer.