HUMAN PRION PROTEIN CDNA - MOLECULAR-CLONING, CHROMOSOMAL MAPPING, AND BIOLOGICAL IMPLICATIONS
HUMAN PRION PROTEIN CDNA - MOLECULAR-CLONING, CHROMOSOMAL MAPPING, AND BIOLOGICAL IMPLICATIONS
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DOI：
10.1126/science.3014653
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发表时间：
1986-07-18
期刊：
影响因子：
56.9
通讯作者：
SMUCKLER, EA
中科院分区：
文献类型：
--
作者：
LIAO, YCJ;LEBO, RV;SMUCKLER, EA
一种人类互补DNA，其蛋白质产物被认为是克雅氏病、库鲁病和Gerstmann-Straussler综合征中瘙痒症相关原纤维的主要成分，已被鉴定和表征。该基因序列与仓鼠PrP 27- 30千道尔顿朊病毒蛋白互补DNA克隆的广泛同源性，以及其在人类基因组中作为单拷贝存在，导致得出结论，这是人类朊病毒基因。这种人类朊病毒基因被定位在人类20号染色体上，否定了朊病毒蛋白与唐氏综合症或阿尔茨海默氏病的淀粉样蛋白之间的直接联系。
A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.