Tic disorders: Neural circuits, neurochemistry, and neuroimmunology
Tic disorders: Neural circuits, neurochemistry, and neuroimmunology
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DOI：
10.1177/08830738060210080901
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发表时间：
2006-08-01
影响因子：
1.9
通讯作者：
Singer, Harvey S.
中科院分区：
文献类型：
--
作者：
Harris, Kendra;Singer, Harvey S.
抽动障碍背后的神经解剖学和神经化学被认为涉及皮质纹状体丘脑皮层回路及其组成神经递质系统的失调。抽动秽语综合症是一种抽动障碍，开始于儿童时期，并遵循一个起起落落的抽动严重程度的过程。虽然普遍认为它有遗传成分，但其病因尚未完全阐明。与链球菌感染相关的儿童自身免疫性神经精神疾病（PANDAS）的临床实体导致一些人认为某些个体的抽搐的病理生理可能涉及感染后自身免疫成分。我们回顾了图雷特综合征的神经回路和神经化学，并评估了支持和反对自身免疫在抽搐表达中的作用的证据。
The neuroanatomy and neurochemistry underlying tic disorders are thought to involve corticostriatothalamocortical circuits and dysregulation of their component neurotransmitter systems. Tourette syndrome is a tic disorder that begins in childhood and follows a waxing and waning course of tic severity. Although it is generally believed to have a genetic component, its etiology has not been fully elucidated. The clinical entity pediatric autoinimune neuropsychiatric disorders associated with streptococcal infection (PANDAS) has led some to suggest that the pathophysiology of tics in some individuals might involve a postinfectious autoimmune component. We review the neural circuits and neurochemistry of Tourette syndrome and evaluate the evidence for and against a role for autoimmunity in the expression of tics.