Fatty liver index (FLI) and prediction of new cases of non-alcoholic fatty liver disease: A population-based study of northern Iran
Fatty liver index (FLI) and prediction of new cases of non-alcoholic fatty liver disease: A population-based study of northern Iran
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DOI：
10.1016/j.clnu.2019.02.024
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发表时间：
2020-02-01
影响因子：
6.3
通讯作者：
Zamani, Farhad
中科院分区：
文献类型：
--
作者：
Motamed, Nima;Faraji, Amir Hossein;Zamani, Farhad
背景和目的：非酒精性脂肪肝被认为是一个主要的公共卫生问题。对可能患上这种疾病的个体的预测将是有价值的。脂肪肝指数（FLI）是一种非侵入性的方法，已显示出良好的能力，区分个体与非酒精性脂肪肝疾病（NAFLD）。因此，本研究评估了FLI预测NAFLD新发病例的能力，随访7年。材料和方法：这项研究是基于对2009-2010年没有NAFLD但在2016-2017年获得这种疾病的个体的随访结果。在2009-2010年，共有2241名没有NAFLD的人在7年后接受了超声评估，以诊断新的NAFLD病例。根据队列研究的I期（2009-2010年进行）数据计算FLI。进行ROC分析以评估FLI在诊断NAFLD新发病例中的预测能力。结果：FLI在男性和女性中的相关AUC分别为0.712（95%CI = 0.675-0.749）和0.721（95%CI = 0.683-0.759）。基于目前的研究结果，在男性和女性的多因素logistic回归分析中，FLI显示与NAFLD显著相关（OR（95%CI = 1.038（1.029-1.047），p值
Background and aims: Non-alcoholic fatty liver disease is considered a major public health concern. The prediction of individuals who can acquire this disease would be valuable. The fatty liver index (FLI) is a non-invasive approach that has shown a good capability for discriminating individuals with nonalcoholic fatty liver disease (NAFLD) from those without it. Thus, this study evaluated the ability of the FLI to predict new cases of NAFLD following a 7-year follow up.Materials and methods: This study was based on the results of follow-up on individuals who did not have NAFLD in 2009-2010, but acquired the disease by 2016-2017. A total of 2241 people who did not have NAFLD in 2009-2010 were evaluated 7 years later by ultrasound so as to diagnose new cases of NAFLD. The FLI was calculated based on data from phase 1 (performed in 2009-2010) of the cohort study. ROC analyses were performed to estimate the predictive ability of the FLI in the diagnosis of new cases of NAFLD. Logistic regression analysis was performed, in which the FLI was considered the predictor and new cases of NAFLD was the outcome.Results: The related AUCs for the FLI in men and women were 0.712 (95% CI = 0.675-0.749) and 0.721 (95% CI = 0.683-0.759), respectively. Based on the current findings, the FLI showed a significant association with NAFLD in multiple logistic regression analyses in both men and women (OR (95% CI= 1.038 (1.029-1.047), p-value