Nutrient regulation of the flow of genetic information by O-GlcNAcylation.
Nutrient regulation of the flow of genetic information by O-GlcNAcylation.
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DOI：
10.1042/bst20200769
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发表时间：
2021-03
影响因子：
3.9
通讯作者：
Yi Zhu;G. Hart
中科院分区：
文献类型：
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作者：
Yi Zhu;G. Hart
O-连接-β-N-乙酰氨基葡萄糖(O-GlcNAc)是一种翻译后修饰，它主动地添加和去除成千上万的细胞内蛋白质。作为一种PTM，O-GlcN酰化以多种方式调节蛋白质的功能，如酶活性、转录活性、亚细胞定位、分子间相互作用和降解。它的调节作用经常与同一蛋白质的磷酸化相互作用。在“中央法则”的支配下，遗传信息流是所有细胞活动的中心。许多调节这种流动的蛋白质都是O-GlcNAc修饰的，它们的功能是由循环糖调节的。在此，我们综述了O-GlcN酰化在表观基因组、DNA复制和修复、转录和RNA加工、蛋白质翻译和蛋白质周转中的调节作用。
O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is actively added to and removed from thousands of intracellular proteins. As a PTM, O-GlcNAcylation tunes the functions of a protein in various ways, such as enzymatic activity, transcriptional activity, subcellular localization, intermolecular interactions, and degradation. Its regulatory roles often interplay with the phosphorylation of the same protein. Governed by 'the Central Dogma', the flow of genetic information is central to all cellular activities. Many proteins regulating this flow are O-GlcNAc modified, and their functions are tuned by the cycling sugar. Herein, we review the regulatory roles of O-GlcNAcylation on the epigenome, in DNA replication and repair, in transcription and in RNA processing, in protein translation and in protein turnover.