Cross-coupling reactions of potassium alkyltrifluoroborates with aryl and 1-alkenyl trifluoromethanesulfonates
Cross-coupling reactions of potassium alkyltrifluoroborates with aryl and 1-alkenyl trifluoromethanesulfonates
复制标题
DOI：
10.1021/ol006896u
复制
发表时间：
2001-02-08
期刊：
影响因子：
5.2
通讯作者：
Ito, T
中科院分区：
文献类型：
--
作者：
Molander, GA;Ito, T
[图解]钯催化的烷基三氟硼酸钾与芳基或烯基三氟酸盐的偶联反应以高产率得到相应的芳烃或烯烃。贝壳都是固体，在空气中稳定，因此可以无限期地储存在货架上。可以使用PdCl2(Dppf)实现交叉耦合。在有CS2CO3存在的情况下，CH2Cl2作为THF-H2O中的催化剂，在BERATE和/或三氟化偶联伙伴中可以容忍各种官能团。
[GRAPHICS]The palladium-catalyzed coupling reaction of potassium alkyltrifluoroborates with aryl- or alkenyltriflates proceeds to afford the corresponding arenes or alkenes in high yield. The berates are all solids, stable in air, and thus can be stored on the shelf indefinitely. The cross coupling can be effected using PdCl2(dppf). CH2Cl2 as the catalyst in THF-H2O in the presence of CS2CO3 A variety of functional groups can be tolerated within the berate and/or the triflate coupling partner.