Set7 methyltransferase roles in myocardial protection from chronic stressors
Set7 methyltransferase roles in myocardial protection from chronic stressors
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Set7 甲基转移酶在慢性应激源心肌保护中的作用
DOI：
10.1042/cs20220773
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发表时间：
2023
期刊：
影响因子：
6
通讯作者：
Pearson James?T.
中科院分区：
文献类型：
--
作者：
小室一成 (今崎剛;仁田英里子;仁田亮 (分担執筆));Pearson James?T.
慢性心血管应激状态（包括糖尿病、压力超负荷和心肌病）中的表观基因组变化经常涉及开放染色质的变化和特定氨基酸位置处组蛋白赖氨酸残基通过乙酰化、甲基化和磷酸化的翻译后修饰。自从Set7作为组蛋白H3赖氨酸4甲基化状态的重要调节因子被发现以来，其在心血管重构和心功能障碍中的作用引起了广泛的兴趣。最近的转录组和傅立叶变换红外光谱分析以及Lunardon及其同事对心脏功能的体内评估揭示了Set7在调节细胞外基质组成和心脏肥大中的明确作用，以响应慢性异丙肾上腺素诱导的心脏应激。
Epigenome changes in chronic states of cardiovascular stress including diabetes, pressure overload and cardiomyopathies frequently involve changes in open chromatin and post-translation modifications of histone lysine residues at specific amino acid positions by acetylation, methylation and phosphorylation. Since the discovery of Set7 as an important regulator of histone H3 lysine 4 methylation state, there has been wide interest in its role in cardiovascular remodeling and cardiac dysfunction. Recent transcriptome and Fourier transform infrared spectroscopy analyses andin vivoassessments of cardiac function by Lunardon and colleagues now reveal a clear role of Set7 in the regulation of the extracellular matrix composition and cardiac hypertrophy in response to chronic isoproterenol induced cardiac stress.