Five cases of aconite poisoning: Toxicokinetics of aconitines
Five cases of aconite poisoning: Toxicokinetics of aconitines
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DOI：
10.1093/jat/31.3.132
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发表时间：
2007-04-01
影响因子：
2.5
通讯作者：
Endo, Shigeatsu
中科院分区：
文献类型：
--
作者：
Fujita, Yuji;Terui, Katsutoshi;Endo, Shigeatsu
本文报告了5例（4男1女）砷中毒患者，年龄49 ~ 78岁。心电图结果如下：病例1室性心动过速和室颤，病例2室性早搏和室性自主节律加速，病例3 AIVR，病例4和5非持续性室性心动过速。病例1的患者因血流动力学不稳定而接受经皮心肺支持，而其他患者则接受补液和抗心律失常药物治疗。在五个病例中，每个患者的主要乌头碱生物碱的半衰期范围为5.8至15.4小时，其他检测到的生物碱的半衰期与每个病例中主要生物碱的半衰期相似。情况1中主要生物碱的半衰期约为其他情况中半衰期的两倍，仅在情况1中观察到血药浓度-时间曲线下面积和平均滞留时间的高值。这些结果表明，生物碱毒代动力学参数可能反映中毒症状的严重程度在乌头中毒。
Aconite poisoning was examined in five patients (four males and one female) aged 49 to 78 years old. The electrocardiogram findings were as follows: ventricular tachycardia and ventricular fibrillation in case 1, premature ventricular contraction and accelerated idioventricular rhythm in case 2, AIVR in case 3, and nonsustained ventricular tachycardia in cases 4 and 5. The patient in case 1 was given percutaneous cardiopulmonary support because of unstable hemodynamics, whereas the other patients were treated with fluid replacement and antiarrhythmic agents. The main aconitine alkaloid in each patient had a half-life that ranged from 5.8 to 15.4 h over the five cases, and other detected alkaloids had half-lives similar to the half-life of the main alkaloid in each case. The half-life of the main alkaloid in case 1 was about twice as long as the half-lives in the other cases, and high values for the area under the blood concentration-time curve and the mean residence time were only observed in case 1. These results suggest that alkaloid toxicokinetics parameters may reflect the severity of toxic symptoms in aconite poisoning.