Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population
Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population
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DOI：
10.1038/ejcn.2010.36
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发表时间：
2010-06-01
影响因子：
4.7
通讯作者：
Cooney, R. V.
中科院分区：
文献类型：
--
作者：
Chai, W.;Maskarinec, G.;Cooney, R. V.
尽管一些证据表明维生素D对乳腺癌有保护作用，但流行病学研究结果并不一致。本研究探讨血清25-羟基维生素D （25(OH) D）水平与乳腺x线摄影密度的关系。182名绝经前妇女的基线血清样本，包括来自营养试验的67名白种人和74名亚洲人，分析25(OH) d。使用计算机辅助方法评估乳房x线摄影密度。在调整混杂因素（体重指数（BMI）、乳房x光检查年龄、亚洲种族、第一胎年龄、胎次和月经初潮年龄）后，血清25(OH) D与乳房x光检查密度无关。亚洲人的25(OH) D水平明显低于白种人，但在调整BMI后，在乳房x线摄影密度方面没有观察到显著的种族差异。尽管目前的研究结果表明，绝经前妇女血清25(OH) D水平与乳房x线摄影密度无关，但维生素D对乳腺癌的保护作用可能通过其他途径介导。欧洲临床营养学杂志（2010）64,652 -654；doi: 10.1038 / ejcn.2010.36;2010年3月10日在线发布
Although some evidence suggests a protective role of vitamin D against breast cancer, epidemiological findings are inconsistent. The current study investigated the relation of serum 25-hydroxyvitamin D (25(OH) D) levels with mammographic density. Baseline serum samples from 182 premenopausal women including 67 Caucasians and 74 Asians from a nutritional trial were analyzed for 25(OH) D. Mammographic density was assessed using a computer-assisted method. Serum 25(OH) D was not associated with mammographic density after adjustment for confounders (body mass index (BMI), age at mammogram, Asian ethnicity, age at first birth, parity and age at menarche). 25(OH) D levels were significantly lower in Asians than in Caucasians, but no significant ethnic differences in mammographic density were observed after adjusting for BMI. Although the current results indicate that serum 25(OH) D levels were not associated with mammographic density among premenopausal women, a possible protective effect of vitamin D against breast cancer may be mediated through other pathways. European Journal of Clinical Nutrition (2010) 64, 652-654; doi:10.1038/ejcn.2010.36; published online 10 March 2010