Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from 2012 to 2015
Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from 2012 to 2015
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DOI：
10.1136/bmjopen-2016-011865
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发表时间：
2017-01-01
期刊：
影响因子：
2.9
通讯作者：
BinSaeed, A.
中科院分区：
文献类型：
--
作者：
Alhamlan, F. S.;Majumder, M. S.;BinSaeed, A.
目的截至2015年11月1日，沙特卫生部报告了1273例中东呼吸综合征(MERS)病例，其中包括在几家医院爆发的9例，717例(56%)患者康复，14例(1%)仍在住院，543例(43%)死亡。本研究旨在确定2012年至2015年沙特阿拉伯MERS暴发期间感染的区别病例与零星感染(即未暴发)病例的流行病学、人口学和临床特征。对2012年9月至2015年10月沙特卫生部确认暴发和未暴发的MERS冠状病毒(CoV)感染病例的设计数据进行摘要和分析。结果共报告MERS冠状病毒感染者1250例，年龄0~109岁，平均50.825岁。在所有中东呼吸综合征病例中，约三分之二是暴发和非暴发病例的男性确诊病例。医护人员占所有MERS暴发和非暴发病例的22%。医院感染占沙特MERS病例的三分之一；然而，暴发病例的医院感染发生率高于非暴发病例(p
Objectives As of 1 November 2015, the Saudi Ministry of Health had reported 1273 cases of Middle East respiratory syndrome (MERS); among these cases, which included 9 outbreaks at several hospitals, 717 (56%) patients recovered, 14 (1%) remain hospitalised and 543 (43%) died. This study aimed to determine the epidemiological, demographic and clinical characteristics that distinguished cases of MERS contracted during outbreaks from those contracted sporadically (ie, non-outbreak) between 2012 and 2015 in Saudi Arabia.Design Data from the Saudi Ministry of Health of confirmed outbreak and non-outbreak cases of MERS coronavirus (CoV) infections from September 2012 through October 2015 were abstracted and analysed. Univariate and descriptive statistical analyses were conducted, and the time between disease onset and confirmation, onset and notification and onset and death were examined.Results A total of 1250 patients (aged 0-109years; mean, 50.825years) were reported infected with MERS-CoV. Approximately two-thirds of all MERS cases were diagnosed in men for outbreak and non-outbreak cases. Healthcare workers comprised 22% of all MERS cases for outbreak and non-outbreak cases. Nosocomial infections comprised one-third of all Saudi MERS cases; however, nosocomial infections occurred more frequently in outbreak than non-outbreak cases (p