Class III viral membrane fusion proteins.

Class III viral membrane fusion proteins.
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DOI:
10.1016/j.sbi.2009.02.012
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发表时间:
2009-04
影响因子:
6.8
通讯作者:
Jardetzky, Theodore S.
Jardetzky, Theodore S.
中科院分区:
生物学2区
文献类型:
--
作者:
Backovic, Marija;Jardetzky, Theodore S.

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Accumulating structural studies of viral fusion glycoproteins have revealed unanticipated structural relationships between unrelated virus families and allowed the grouping of these membrane fusogens into three distinct classes. Here we review the newly identified group of class III viral fusion proteins, whose members include fusion proteins from rhabdoviruses, herpesviruses and baculoviruses. While clearly related in structure, the class III viral fusion proteins exhibit distinct structural features in their architectures as well as in their membrane-interacting fusion loops, which are likely related to their virus-specific differences in cellular entry. Further study of the similarities and differences in the class III viral fusion glycoproteins may provide greater insights into protein:membrane interactions that are key to promoting efficient bilayer fusion during virus entry.
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