Evaluation of two polymeric blends (EVA/PLA and EVA/PEG) as coating film materials for paclitaxel-eluting stent application
Evaluation of two polymeric blends (EVA/PLA and EVA/PEG) as coating film materials for paclitaxel-eluting stent application
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两种聚合物共混物（EVA/PLA 和 EVA/PEG）作为紫杉醇洗脱支架涂膜材料的评估
DOI：
10.1007/s10856-010-4213-3
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发表时间：
2011-02-01
影响因子：
3.7
通讯作者：
Chen, Ke-Min
中科院分区：
文献类型：
--
作者：
Liu, Xi;Lei, Lei;Chen, Ke-Min
采用乙烯-醋酸乙烯共聚物（伊娃）/聚乳酸（PLA）共混物和伊娃/聚乙二醇（PEG）共混物作为载药材料，制备了紫杉醇（PTX）载药层和无药伊娃层的双层载药支架涂层膜。通过X射线衍射（XRD）、凝胶渗透色谱（GPC）和扫描电子显微镜（SEM）分析了无药共混膜的重量和外观随时间的变化，结果表明PLA降解，PEG从膜中浸出。考察了聚乳酸、聚乙二醇和药物含量对药物体外释放的影响，结果表明聚乳酸的加入促进了药物的释放，而聚乙二醇的加入几乎没有促进药物的释放。Franz细胞扩散试验结果表明，双层结构成功地赋予了支架涂层以单向方式释放药物。结合PTX的膜的释放曲线和膜的机械性能可以通过容易地调节共混物组分的含量来定制。因此，聚合物共混物可以是用于载药支架涂层的有用的药物载体材料，其能够以高度可调的方式释放药物。
The ethylene vinyl acetate copolymer (EVA)/Poly (lactic acid) (PLA) blend and EVA/Poly (ethylene glycol) (PEG) blend were applied as the drug carrier materials for a bi-layer drug-loaded stent coating film, which consisted of a paclitaxel (PTX)-loaded layer and a drug-free EVA layer. The changes of weight and appearance of the drug-free polymeric blend films with increasing time were examined by X-ray diffraction analysis (XRD), gel permeation chromatography (GPC) tests and scanning electronic microscopy (SEM), and the results showed the degradation of PLA and the leaching of PEG from the films. The effects of PLA, PEG and drug contents on in vitro drug release were investigated, and the results demonstrated that the addition of PLA promoted the drug release while the addition of PEG almost did not. Franz cells diffusion test results indicated that the bi-layer structure successfully endowed the stent coating with the release of drug in a unidirectional fashion. The release profiles of films incorporated PTX and the mechanical performance of the film could be customized by readily adjusting the contents of the blend components. Therefore, the polymeric blends could be useful drug carrier materials for drug-loaded stent coating capable of releasing drug in a highly tunable manner.