THE PROGRESSION OF EROSION AND JOINT SPACE NARROWING SCORES IN RHEUMATOID-ARTHRITIS DURING THE 1ST 25 YEARS OF DISEASE
THE PROGRESSION OF EROSION AND JOINT SPACE NARROWING SCORES IN RHEUMATOID-ARTHRITIS DURING THE 1ST 25 YEARS OF DISEASE
复制标题
DOI：
10.1002/art.1780340606
复制
发表时间：
1991-06-01
影响因子：
--
通讯作者：
BLOCH, DA
中科院分区：
文献类型：
--
作者：
SHARP, JT;WOLFE, F;BLOCH, DA
侵蚀和软骨破坏几乎是慢性类风湿性关节炎影响的外周关节的普遍特征。 已经开发了测量手和手腕这些异常程度的评分方法，并在几项研究中进行了彻底测试，以确定其重现性。 在这项研究中，我们利用这些评分方法之一来检查与疾病持续时间相关的放射学损害的进展。 纳入了来自关节炎、风湿病和衰老医学信息系统3个不同参与中心的292例患者。 从210名患者中获得的650张手和手腕的照片，对侵蚀和关节间隙狭窄进行评分。 在发病后的前25年内，总放射学评分的平均年进展率约为4个单位/年，总放射学评分将侵蚀和关节间隙异常相加，最大可能评分为314;这种进展在疾病的早期更快，在后期稍慢。 数据不足以准确确定病程超过25年的疾病的进展率。
Erosions and cartilage destruction are nearly universal features in peripheral joints that have been chronically affected by rheumatoid arthritis. Scoring methods to measure the extent of these abnormalities in hands and wrists have been developed and have been thoroughly tested in several studies to establish their reproducibility. In this study, we utilized one of these scoring methods to examine the progression of radiologic damage as related to duration of disease. Two hundred ninety-two patients from 3 different participating centers in the Arthritis, Rheumatism, and Aging Medical Information System were included. Six hundred fifty films of the hands and wrists, obtained from 210 patients, were scored for erosions and joint space narrowing. The average annual rate of progression of the total radiologic score, which sums erosion and joint space abnormalities and has a maximum possible score of 314, was approximately 4 units per year over the first 25 years after onset; this progression was more rapid in the earlier years of disease and slightly slower in the later years. Data were insufficient to accurately determine the progression rate in disease of more than 25 years duration.