Passenger mutations as a marker of clonal cell lineages in emerging neoplasia.
Passenger mutations as a marker of clonal cell lineages in emerging neoplasia.
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DOI：
10.1016/j.semcancer.2010.10.008
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发表时间：
2010-10
影响因子：
14.5
通讯作者：
Horwitz MS
中科院分区：
文献类型：
--
作者：
Salk JJ;Horwitz MS
癌症的产生是身体细胞之间自然选择过程的结果，有利于携带体细胞突变的谱系，从而赋予它们增殖优势。在肿瘤内的数千个突变中，只有一小部分在功能上驱动其生长；绝大多数人只是生物后果极小的乘客。然而，任何突变的存在，无论其在促进增殖中的作用如何，都会以某种方式标记细胞的克隆后代，使它们能够与不相关的细胞区分开来。此类细胞谱系标记可用于识别肿瘤性克隆进化的异常增殖特征，即使是在形态学上可识别的发育不良之前的阶段。本文重点介绍用于评估人类细胞克隆性的分子技术，重点是如何将它们用于早期检测致瘤过程。我们讨论历史和当代的方法，并考虑如何利用强大的新基因组技术来开发下一代早期癌症诊断。
Cancer arises as the result of a natural selection process among cells of the body, favoring lineages bearing somatic mutations that bestow them with a proliferative advantage. Of the thousands of mutations within a tumor, only a small fraction functionally drive its growth; the vast majority are mere passengers of minimal biological consequence. Yet the presence of any mutation, independent of its role in facilitating proliferation, tags a cell’s clonal descendants in a manner that allows them to be distinguished from unrelated cells. Such markers of cell lineage can be used to identify the abnormal proliferative signature of neoplastic clonal evolution, even at a stage which predates morphologically recognizable dysplasia. This article focuses on molecular techniques for assessing cellular clonality in humans with an emphasis on how they may be used for early detection of tumorigenic processes. We discuss historical as well as contemporary approaches and consider ways in which powerful new genomic technologies might be harnessed to develop a future generation of early cancer diagnostics.
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影响因子：
64.8
作者：
通讯作者：
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影响因子：
64.5
作者：
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通讯作者：
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通讯作者：
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DOI：
10.1073/pnas.0801523105
发表时间：
2008-09-02
影响因子：
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作者：
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通讯作者：
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作者：
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