Both central command and exercise pressor reflex activate cardiac sympathetic nerve activity in decerebrate cats.
Both central command and exercise pressor reflex activate cardiac sympathetic nerve activity in decerebrate cats.
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中枢指令和运动升压反射都会激活去大脑猫的心脏交感神经活动。
DOI：
10.1152/ajpheart.01219.2008
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Kaufman,MarcP
中科院分区：
文献类型：
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作者：
Tsuchimochi,Hirotsugu;Hayes,ShawnG;McCord,JenniferL;Kaufman,MarcP
已知静态和动态运动都能增加心脏泵功能以及动脉血压。中枢指令的前馈控制和运动加压反射的反馈控制被认为是运动中产生这些效应的神经机制。目前尚不清楚，以如何每一种机制激活心脏交感神经活动（CSNA）在运动中，特别是在其发病。因此，我们检查了CSNA对中脑运动区（MLR，即，中枢指令）和去大脑猫中小腿三头肌的静态肌肉收缩或跟骨肌腱的伸展。我们发现，MLR刺激立即增加CSNA，其次是逐渐增加的心率，平均动脉压，和腹根活动的刺激强度依赖性的方式。从MLR刺激开始的CSNA增加的潜伏期范围从67到387毫秒。静态收缩和肌腱拉伸也迅速增加CSNA。他们的潜伏期从发展的紧张反应腹根刺激范围从78到670毫秒。这些研究结果表明，中央命令和肌肉机械反射发挥作用，在运动开始时控制心脏交感神经流出。
Both static and dynamic exercise are known to increase cardiac pump function as well as arterial blood pressure. Feedforward control by central command and feedback control by the exercise pressor reflex are thought to be the neural mechanisms causing these effects during exercise. It remains unknown as to how each mechanism activates cardiac sympathetic nerve activity (CSNA) during exercise, especially at its onset. Thus we examined the response of CSNA to stimulation of the mesencephalic locomotor region (MLR, i.e., central command) and to static muscle contraction of the triceps surae muscles or stretch of the calcaneal tendon in decerebrate cats. We found that MLR stimulation immediately increased CSNA, which was followed by a gradual increase in heart rate, mean arterial pressure, and ventral root activity in a stimulus intensity-dependent manner. The latency of the increase in CSNA from the onset of MLR stimulation ranged from 67 to 387 ms. Both static contraction and tendon stretch also rapidly increased CSNA. Their latency from the development of tension in response to ventral root stimulation ranged from 78 to 670 ms. These findings suggest that both central command and the muscle mechanoreflex play a role in controlling cardiac sympathetic outflow at the onset of exercise.