Allogeneic blood stem cell transplantation after a reduced‐intensity, preparative regimen
Allogeneic blood stem cell transplantation after a reduced‐intensity, preparative regimen
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降低强度的准备方案后的同种异体造血干细胞移植
作者：
P. Pedrazzoli;G. D. Da Prada;G. Giorgiani;R. Schiavo;A. Zambelli;E. Giraldi;G. Landonio;F. Locatelli;S. Siena;G. R. Cuna
免疫介导的移植物抗肿瘤（GVT）效应在接受同种异体造血干细胞移植（HSCT）的血液系统恶性肿瘤患者的治疗中起着治疗作用。最近，有报道称GVT效应也发生在接受转移性肾癌移植的患者中。作者对难治性恶性肿瘤（包括实体瘤）患者进行了低强度预备治疗后的同种异体移植的试点试验。本研究的目的是评估这种方法在毒性和植入方面的可行性，并记录GVT效应的证据。
The immune‐mediated graft‐versus‐tumor (GVT) effect plays a therapeutic role in the treatment of patients with hematologic malignancies who undergo allogeneic hematopoietic stem cell transplantation (HSCT). More recently, it was reported that a GVT effect also occurred in patients who underwent transplantation for metastatic renal carcinoma. The authors carried out a pilot trial of allogeneic transplantation after a reduced‐intensity, preparative regimen in patients with refractory malignancies, including solid tumors. The objectives of the current study were to evaluate the feasibility of this approach in terms of toxicity and engraftment and to document evidence of GVT effects.
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影响因子：
20.3
作者：
Stephen Mackinnon;L. Barnett;Jean Bourhis;P. Black;G. Heller;R. O'reilly
通讯作者：
Stephen Mackinnon;L. Barnett;Jean Bourhis;P. Black;G. Heller;R. O'reilly
影响因子：
20.3
作者：
McSweeney, PA;Niederwieser, D;Storb, RF
通讯作者：
Storb, RF
影响因子：
20.3
作者：
M. Horowitz;R. Gale;P. Sondel;J. Goldman;J. Kersey;H. Kolb;A. Rimm;O. Ringdén;C. Rozman
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M. Horowitz;R. Gale;P. Sondel;J. Goldman;J. Kersey;H. Kolb;A. Rimm;O. Ringdén;C. Rozman
影响因子：
20.3
作者：
Childs, R;Clave, E;Barrett, AJ
通讯作者：
Barrett, AJ
影响因子：
20.3
作者：
Giralt, S;Estey, E;Champlin, R
通讯作者：
Champlin, R