Galectin-3, a marker of well-differentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia
Galectin-3, a marker of well-differentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia
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DOI：
10.1046/j.1365-2559.2002.01304.x
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发表时间：
2002-01-01
期刊：
影响因子：
6.4
通讯作者：
Massi, G
中科院分区：
文献类型：
--
作者：
Coli, A;Bigotti, G;Massi, G
目的：对95例甲状腺病变（包括结节伴非典型型灶）中半乳糖凝集素-3的分布进行了研究。半乳糖凝集素-3是公认的高分化甲状腺癌标志物。方法和结果：乳头状癌28例，滤泡性癌5例，Hurthle细胞癌1例，低分化癌3例，间变性癌1例，结节性增生25例，滤泡性腺瘤27例，其中结节不典型，恶性潜能未定3例，甲状腺炎2例。免疫组化发现半乳糖凝集素-3在肿瘤中一致存在；另外，良性结节表现为半凝集素-3阳性细胞簇，具有分化癌（主要是乳头状型）发育不良的特征，如核染色质清除、核裂裂、假内含物，在每种情况下，组织学上不足以保证恶性肿瘤的明确诊断。在其他结节中半乳糖凝集素-3染色为阴性。与半乳糖凝集素-3阳性的病例相比，后者要么是明显良性的，要么表现出持续轻微的染色质清除和其他不典型特征。结论：半乳糖凝集素-3是分化型甲状腺癌的可靠标志物，在我们的一系列恶性肿瘤中得到证实，它在整体良性的结节中表达，但灶性区域可疑为恶性肿瘤。这些发现的意义需要进一步调查。
Aims: The distribution of galectin-3, a widely recognized marker of well-differentiated thyroid carcinoma, was investigated in 95 thyroid lesions including nodules with foci of cytoarchitectural atypia.Methods and results: Twenty-eight papillary carcinomas, five follicular carcinomas, one Hurthle cell carcinoma, three poorly differentiated carcinomas, one anaplastic carcinoma, 25 nodular hyperplasias and 2 7 follicular adenomas, including nodules with atypical features, three neoplasms of undetermined malignant potential and two thyroiditis cases were examined. By immunohistochemistry, galectin-3 was consistently found in carcinomas; otherwise benign nodules exhibited galectin-3-positive clusters of cells with poorly developed features of differentiated carcinoma (mainly of papillary type) such as nuclear chromatin clearing, nuclear clefting, pseudoinclusions, which, in each case, were not histologically sufficient to warrant a definitive diagnosis of malignancy. In other nodules galectin-3 staining was negative. The latter were either clearly benign or showed constantly a minor degree of chromatin clearing and of other atypical features when compared with galectin-3-positive cases.Conclusions: Galectin-3, a reliable marker of differentiated thyroid carcinoma as confirmed in our series of malignant neoplasms, appears expressed in nodules with an overall benign appearance but with focal areas suspicious for malignancy. The significance of such findings needs to be further investigated.