Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study.
Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study.
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大脑功能连接异常导致甲状腺功能亢进患者情绪和认知受损：一项静息态功能 MRI 研究
DOI：
10.18632/oncotarget.14060
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发表时间：
2017-01-24
期刊：
影响因子：
--
通讯作者：
Yuan Y
中科院分区：
文献类型：
--
作者：
Li L;Zhi M;Hou Z;Zhang Y;Yue Y;Yuan Y
甲状腺机能亢进患者常伴有神经精神疾患，如注意力不集中、记忆力差、抑郁、焦虑、紧张和易怒，提示脑功能障碍。然而，这些症状的潜在过程尚不清楚。使用静息状态功能磁共振成像（rs-fMRI），我们描述了33名甲状腺功能亢进患者相对于33名健康对照者的改变图理论度量度中心性（DC）和基于种子的静息状态功能连通性（FC）。将两组间DC变化显著的峰值点定义为计算全脑FC的种子区。然后对DC、FC异常与神经心理表现及部分临床指标进行偏相关分析。本研究中小脑后叶（PLC）和内侧额回（MeFG）固有功能连通性下降，以及锚定在默认模式网络（DMN）、注意网络、视觉网络和认知网络中的异常种子型FC，可能是甲亢患者焦虑和加工速度受损等情绪和认知变化的潜在机制。
Patients with hyperthyroidism frequently have neuropsychiatric complaints such as lack of concentration, poor memory, depression, anxiety, nervousness, and irritability, suggesting brain dysfunction. However, the underlying process of these symptoms remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI), we depicted the altered graph theoretical metric degree centrality (DC) and seed-based resting-state functional connectivity (FC) in 33 hyperthyroid patients relative to 33 healthy controls. The peak points of significantly altered DC between the two groups were defined as the seed regions to calculate FC to the whole brain. Then, partial correlation analyses were performed between abnormal DC, FC and neuropsychological performances, as well as some clinical indexes. The decreased intrinsic functional connectivity in the posterior lobe of cerebellum (PLC) and medial frontal gyrus (MeFG), as well as the abnormal seed-based FC anchored in default mode network (DMN), attention network, visual network and cognitive network in this study, possibly constitutes the latent mechanism for emotional and cognitive changes in hyperthyroidism, including anxiety and impaired processing speed.