Heritability of Hippocampal Formation Sub-region Volumes.
Heritability of Hippocampal Formation Sub-region Volumes.
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DOI：
10.21767/2171-6625.1000159
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
K. Greenspan;Claire R Arakelian;T. V. van Erp
中科院分区：
文献类型：
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作者：
K. Greenspan;Claire R Arakelian;T. V. van Erp
海马形成（HF）的体积和情景记忆的表现是基本上遗传的，但HF亚区遗传力估计和他们可能共享的遗传方差与情景记忆的表现仍有待确定。方法和发现本研究提供了海马亚区（例如，阿蒙角、下托、副下托、齿状回灰质的分子和颗粒细胞层）的遗传性估计值以及使用FreeSurfer 6.0获得的总HF体积。此外，本研究还评估了对象序列和言语情景记忆表现的遗传性，以及HF子区域和总HF体积和情景记忆表现之间共享的遗传方差的量。HF体积是从499名兄弟姐妹（平均年龄±SD=30.0±3.1，203名男性）的高分辨率脑扫描中获得的，包括51对同卵双胞胎和46对异卵双胞胎以及305名非双胞胎兄弟姐妹，由人类连接组计划（www.humanconnectome.org）收集。HF亚区的遗传度估计值范围为0.42-0.87，HF亚区与海马体积的共享遗传方差很大（平均值=0.79，范围=0.50-0.98）。还发现总HF和HF亚区体积百分比的HF亚区体积残差基本上是可遗传的（范围分别为0.04-0.86和0.07-0.84）。言语（H2=0.47），但不是对象序列情景记忆被认为是显着遗传的，虽然HF亚区和言语情景记忆之间的共享遗传方差的量是低的（平均值=0.10，范围=0.01-0.20）。结论这些发现表明HF亚区体积是可遗传的，可以作为遗传关联研究中的定量表型。HF亚区和言语情景记忆之间的低共享遗传方差表明，数量性状分析可能不会受益于包括HF量和情景记忆作为双变量性状在健康个体。HF亚区体积与神经精神疾病共享遗传变异的程度，以及因此增加我们识别这些疾病遗传风险位点的能力的价值，仍有待确定。
BACKGROUND Hippocampal formation (HF) volume and episodic memory performance are substantially heritable, but HF subregion heritability estimates and their possible shared genetic variance with episodic memory performance remain to be determined. METHODS AND FINDINGS This study provides heritability estimates for hippocampal subregions (e.g, Cornu Amonis, Subiculum, Parasubiculum, Molecular and Granule Cell Layers of the Dentate Gryus) and Total HF volumes obtained using FreeSurfer 6.0. In addition, this study assesses the heritability of object sequence and verbal episodic memory performance, and the amount of shared genetic variance between HF subregions and Total HF volume and episodic memory performance. HF volumes were obtained from high-resolution brain scans from a sample of 499 siblings (mean age±SD=30.0±3.1, 203 men), including 51 monozygotic and 46 dizygotic twin pairs and 305 non-twin siblings, collected by the Human Connectome Project (www.humanconnectome.org). Heritability estimates for HF subregions ranged from 0.42-0.87 and shared genetic variance of HF subregions with hippocampal volume was substantial (mean=0.79, range=0.50-0.98). HF subregion volumes residualized for Total HF and percent HF subregion volumes were also found to be substantially heritable (range=0.04-0.86 and 0.07-0.84, respectively). Verbal (h2=0.47) but not object sequence episodic memory was found to be significantly heritable; though the amount of shared genetic variance between HF subregions and verbal episodic memory was low (mean=0.10, range=0.01-0.20). CONCLUSIONS These findings suggest that HF subregion volumes are heritable and can be used as quantitative phenotypes in genetic association studies. The low shared genetic variance between HF subregions and verbal episodic memory suggests that quantitative trait analyses may not benefit from including both HF volume and episodic memory as bivariate traits in healthy individuals. The extent to which HF subregion volumes share genetic variance with neuropsychiatric disorders, and as such add value to our ability to identify genetic risk loci for these disorders, remains to be determined.