Efficacy of a high quality O1/Campos foot-and-mouth disease vaccine upon challenge with a heterologous Korean O Mya98 lineage virus in pigs
Efficacy of a high quality O1/Campos foot-and-mouth disease vaccine upon challenge with a heterologous Korean O Mya98 lineage virus in pigs
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DOI：
10.1016/j.vaccine.2018.02.015
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发表时间：
2018-03-14
期刊：
影响因子：
5.5
通讯作者：
Bergmann, I. E.
中科院分区：
文献类型：
--
作者：
Galdo Novo, S.;Malirat, V.;Bergmann, I. E.
2010年，Mya 98谱系/SEA拓扑型的O型口蹄疫病毒传播到大多数东亚国家。2010-2011年期间，大韩民国爆发了重大疫情，使用单价O/Manisa疫苗（属于ME-SA拓扑型）帮助控制疫情。随后，所有易感动物每6个月接种一次含有O/Manisa抗原的疫苗。尽管接种了疫苗，但这种疾病在2014年再次发生，此后几乎每年都发生。本研究的重点是高质量单价市售O-1/Campos疫苗在猪中对抗来自大韩民国镇川省的2015年代表性分离株的异源攻毒的体内有效性。最初，对2014-2015年期间在该地区回收的6种病毒进行了病毒表征和r（1）测定，重点是它们与充分表征和广泛可用的O-1/Campos疫苗株的关系。遗传和抗原分析表明，2014-2015年韩国分离株与之前的2010年病毒非常相似，与O-1/Campos株存在明显差异。使用O-1/Campos牛和猪接种后血清和最近韩国爆发的病毒进行的病毒中和试验预测，单次接种后的交叉保护可接受，如r（1）值所示，在猪中，通过预期保护。与体外估计值一致，用选定的田间分离株进行的体内攻毒表明O-1/Campos primo接种猪受到保护，导致PD 50值接近10。结果表明，含有O-1/Campos株的高质量油疫苗可成功地用于对抗属于O Mya 98/SEA拓扑型的分离物。(C)2018爱思唯尔有限公司版权所有
In 2010 serotype O foot-and-mouth disease virus of the Mya98 lineage/SEA topotype spread into most East Asian countries. During 2010-2011 it was responsible for major outbreaks in the Republic of Korea where a monovalent O/Manisa vaccine (belonging to the ME-SA topotype) was applied to help control the outbreaks. Subsequently, all susceptible animals were vaccinated every 6 months with a vaccine containing the O/Manisa antigen. Despite vaccination, the disease re-occurred in 2014 and afterwards almost annually. This study focuses on the in vivo efficacy in pigs of a high quality monovalent commercial O-1/Campos vaccine against heterologous challenge with a representative 2015 isolate from the Jincheon Province of the Republic of Korea. Initially, viral characterizations and r(1) determinations were performed on six viruses recovered in that region during 2014-2015, centering on their relationship with the well characterized and widely available O-1/Campos vaccine strain. Genetic and antigenic analysis indicated a close similarity among 2014-2015 Korean isolates and with the previous 2010 virus, with distinct differences with the O-1/Campos strain. Virus neutralisation tests using O-1/Campos cattle and pig post vaccination sera and recent Korean outbreak viruses predicted acceptable cross-protection after a single vaccination, as indicated by r(1) values, and in pigs, by expectancy of protection. In agreement with the in vitro estimates, in vivo challenge with a selected field isolate indicated that O-1/Campos primo vaccinated pigs were protected, resulting in a PD50 value of nearly 10. The results indicated that good quality oil vaccines containing the O-1/Campos strain can successfully be used against isolates belonging to the O Mya98/SEA topotype. (C) 2018 Elsevier Ltd. All rights reserved.