Single-Point Vulnerabilities in Atherosclerotic Plaque.
Single-Point Vulnerabilities in Atherosclerotic Plaque.
复制标题
动脉粥样硬化斑块中的单点漏洞。
DOI：
10.1016/j.jacc.2023.05.001
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发表时间：
2023
影响因子：
24
通讯作者：
Giannarelli,Chiara
中科院分区：
文献类型：
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作者：
Giannarelli,Chiara
人类动脉粥样硬化的自然演变涉及到脆弱状态和破裂的进展，这是人类独有的病理命运。1-6动脉粥样硬化的生长和进展是受血流紊乱模式影响的空间过程。随之而来的血管组织破坏对应于具有区域分布的组织学模式，其是组织病理学斑块分类的组成部分。2传统上，易损易破裂斑块的特征是大的坏死核心、薄的纤维化帽、炎性表型和斑块内出血。这些病理特征及其在组织环境中的独特空间分布导致动脉粥样硬化组织的高度异质性。
The natural evolution of human atherosclerosis involves the progression to a vulnerable state and rupture, a pathologic fate that is exclusive to humans. 1-6 Atherosclerosis growth and progression are spatial processes influenced by disturbed patterns of blood flow. The consequent vascular tissue disorganization corresponds to histologic patterns with regional distributions that are an integral part of histopathologic plaque classification. 2 A vulnerable and prone-to-rupture plaque is traditionally characterized by a large necrotic core, a thin fibrotic cap, an inflammatory phenotype, and intraplaque hemorrhage. 1, 5 These pathologic features and their unique spatial distribution in the tissue context contribute to the highly heterogeneous nature of atherosclerotic tissue.