EMBRYONIC BRAIN ENLARGEMENT REQUIRES CEREBROSPINAL-FLUID PRESSURE
EMBRYONIC BRAIN ENLARGEMENT REQUIRES CEREBROSPINAL-FLUID PRESSURE
复制标题
DOI：
10.1016/0012-1606(77)90364-5
复制
发表时间：
1977-01-01
影响因子：
2.7
通讯作者：
JACOBSON, AG
中科院分区：
文献类型：
--
作者：
DESMOND, ME;JACOBSON, AG
鸡胚脑在孵化第2天开始突然增大。此后不久，大脑发生了严重的弯曲和扭曲，出现了许多隆起和沟槽。椎管扩大的发生与椎管的闭合相一致，这使得神经管成为充满CSF的封闭隔室。脑脊液压力是正常脑增大的必要驱动力。通过对鸡胚脑进行插管，并比较正常和插管胚胎的脑腔和组织体积来验证这一假设。腔体积的增加大大减少，而脑组织继续以降低的速度生长并折叠到脑室中。
The brain of the chick embryo began to enlarge abruptly on the 2nd day of incubation. Shortly thereafter, major flexures and torsions of the brain occurred, and many bulges and furrows appeared. The onset of enlargement coincided with closure of the spinal canal which makes the neural tube a closed compartment filled with CSF. CSF pressure was a necessary driving force for normal brain enlargement. This hypothesis was tested by intubating brains of chick embryos and comparing brain cavity and tissue volumes in normal and intubated embryos. The increased in cavity volume was greatly reduced, whereas brain tissue continued to grow at a reduced rate and folds into the ventricles.