Arterial spin-labeled perfusion MRI in basic and clinical neuroscience
Arterial spin-labeled perfusion MRI in basic and clinical neuroscience
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DOI：
10.1097/wco.0b013e32832d9505
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发表时间：
2009-08-01
影响因子：
4.8
通讯作者：
Rao, Hengyi
中科院分区：
文献类型：
--
作者：
Detre, John A.;Wang, Jiongjiong;Rao, Hengyi
综述目的动脉自旋标记（ASL）为磁共振成像（MRI）定量局部脑血流量（CBF）提供了一种内源性和完全无创的示踪剂。尽管脑血流的测量在脑血管疾病中具有明显的实用性，但由于脑血流与神经代谢密切相关，ASL灌注MRI在基础和临床神经科学中作为局部脑功能的生物标志物具有广泛的潜在应用。本文简要介绍了ASL的方法和临床应用，同时扩展了ASL在人类神经科学研究中的应用，以阐明与基因型或表型相关的静息脑功能模式（trait effects）或响应于用药物或心理任务对脑功能的外源性操纵概述ASL灌注MRI提供了区域脑功能的通用生物标志物，其可以作为多模态MRI检查的一部分来获取。因为ASL量化了生理参数，所以它应该对多部位或纵向研究有用。
Purpose of reviewArterial spin labeling (ASL) provides an endogenous and completely noninvasive tracer for the quantification of regional cerebral blood flow (CBF) with magnetic resonance imaging (MRI). Although the measurement of CBF has obvious utility in cerebrovascular disorders, because CBF is closely coupled to neural metabolism, ASL perfusion MRI has a broad range of potential applications as a biomarker of regional brain function in basic and clinical neuroscience.Recent findingsOver the past few years, ASL technology has improved considerably and the utility of ASL perfusion MRI as a diagnostic and research tool has been demonstrated. This review briefly covers ASL methodologies and clinical applications, while expanding on the use of ASL in human neuroscience research to elucidate patterns of resting brain function that correlate with genotype or phenotype (trait effects), or in response to exogenous manipulations of brain function with pharmacological agents or psychological tasks (slate effects).SummaryASL perfusion MRI provides a versatile biomarker of regional brain function that can be acquired as part of a multimodal MRI examination. Because ASL quantifies a physiological parameter, it should be useful for multisite or longitudinal studies.