Red cell alloimmunization in multi-transfused chronic renal failure patients undergoing hemodialysis.
Red cell alloimmunization in multi-transfused chronic renal failure patients undergoing hemodialysis.
复制标题
接受血液透析的多次输血慢性肾衰竭患者的红细胞同种免疫。
DOI：
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发表时间：
1999
影响因子：
1
通讯作者：
Chaudhary Rk
中科院分区：
文献类型：
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作者：
Shukla Js;Chaudhary Rk
红细胞（RBC）输注经常用于治疗因透析相关贫血而接受血液透析的慢性肾衰竭（CRF）患者。因此，它们会遭受与重复输血相关的所有危险，例如红细胞同种免疫。一项回顾性研究旨在评估多次输血 CRF 患者针对红细胞抗原的同种免疫频率。共有 81 名 CRF 患者（67 名男性和 14 名女性）接受了研究，这些患者平均接受了 8.5 单位仅与 ABO 和 Rh(D) 抗原匹配的红细胞。使用标准技术（间接抗球蛋白测试、酶、聚乙二醇和低离子强度溶液），我们观察到红细胞同种免疫率为 9.8% (8/81)。在 8 名患者中检测到 9 种同种抗体，其中大多数（88%）涉及恒河猴和凯尔系统中的抗原。没有观察到同种抗体形成和输注单位数量的相关性。本研究中观察到的计算风险为 1.3%，表明肾衰竭患者的红细胞同种免疫风险并不比一般人群更高。
Red blood cell (RBC) transfusions are frequently used in the management of patients with chronic renal failure (CRF) undergoing hemodialysis for dialysis-related anaemia. Consequently, they are subject to all hazards associated with repeated transfusions, such as red cell alloimmunization. A retrospective study was performed to estimate the frequency of alloimmunization against red cell antigens in multitransfused CRF patients. A total of 81 patients (67 males & 14 females) with CRF were studied who received a mean of 8.5 units of RBC matched for ABO & Rh(D) antigens only. Using standard techniques (indirect antiglobulin test, enzyme, polyethylene glycol, and low ionic strength solution), we observed a RBC alloimmunization rate of 9.8% (8/81). Nine alloantibodies were detected in 8 patients, and most (88%) involved antigens in the Rhesus & Kell systems. No correlation was observed with the alloantibody formation & number of units transfused. The calculated risk of 1.3% observed in the present study, suggests that renal failure patients are not at a higher risk of red cell alloimmunization than the general population.