The effects of Xanthigen™ in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat
The effects of Xanthigen™ in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat
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DOI：
10.1111/j.1463-1326.2009.01132.x
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发表时间：
2010-01-01
影响因子：
5.8
通讯作者：
Grachev, S.
中科院分区：
文献类型：
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作者：
Abidov, M.;Ramazanov, Z.;Grachev, S.
方法：16周、双盲、随机、安慰剂对照研究。对151例肝脏脂肪含量高于11%(NAFLD)、低于6.5%(NLF)的非糖尿病、肥胖绝经前妇女(NAFLD组113例，NLF组38例)进行为期16周的食物记录、体成分、REE(仅41名NAFLD志愿者)和血样分析。结果：Xanthigen-600/2.4 mg(300 mg PSO+300 mg褐藻提取物含2.4 mg岩藻黄质)可显著减轻体重(NAFLD组5.5+-1.4 kg和NLF组4.9+-1.2 kg，p<)；体重(3.5+/-1.9kgNAFLD组，P<0.0 5；3.6+/-0.7kgNLF组，P<0.0 5)，以及肝脏脂肪含量、肝酶(仅NAFLD组)、血清甘油三酯和C反应蛋白。与非酒精性脂肪肝患者相比，非酒精性脂肪肝患者出现体重减轻和体脂和肝脏脂肪含量减少的时间更早。与安慰剂相比，非酒精性脂肪肝受试者服用岩藻黄质(-gt；2.4 mg)和黄精-400/1.6 mg(200 mg PSO+200 mg褐藻提取物，含1.6 mg岩藻黄质)显著增加稀土元素含量。结论：黄精可促进肥胖非糖尿病女性的体重减轻，降低体脂和肝脂含量，改善肝功能。黄珊瑚和岩藻黄质也增加了稀土元素含量。这种产品可能被认为是一种很有前途的食品补充剂，用于治疗肥胖。
Methods: Sixteen-week, double-blind, randomized, placebo-controlled study. Food record data, body composition, REE (only 41 volunteers with NAFLD) and blood sample analysis were assessed weekly for 16 weeks in 151 non-diabetic, obese premenopausal women with liver fat content above 11% (NAFLD) n = 113, and below 6.5% (NLF) n = 38.Results: Xanthigen-600/2.4 mg (300 mg PSO + 300 mg brown seaweed extract containing 2.4 mg fucoxanthin) resulted in statistically significant reduction of body weight (5.5 +/- 1.4 kg NAFLD group and 4.9 +/- 1.2 kg NLF group, p < 0.05), waist circumference (NAFLD group only), body (3.5 +/- 1.9 kg NAFLD group, p < 0.001; 3.6 +/- 0.7 kg NLF group, p < 0.05) and liver fat content, liver enzymes (NAFLD group only), serum triglycerides and C-reactive protein. Weight loss and reduction in body and liver fat content occurred earlier in patients with NLF than in patients with NAFLD. Fucoxanthin (> 2.4 mg) and Xanthigen-400/1.6 mg (200 mg PSO + 200 mg brown seaweed extract containing 1.6 mg fucoxanthin) significantly increased REE in NAFLD subjects compared to placebo.Conclusions: Xanthigen promoted weight loss, reduced body and liver fat content, and improved liver function tests in obese non-diabetic women. Xanthigen and Fucoxanthin also increased REE. This product may be considered a promising food supplement in the management of obesity.