Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation
Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation
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DOI：
10.1126/science.1137971
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发表时间：
2007-04-27
期刊：
影响因子：
56.9
通讯作者：
Kurts, Christian
中科院分区：
文献类型：
--
作者：
Burgdorf, Sven;Kautz, Andreas;Kurts, Christian
允许抗原呈递细胞（APC）选择性地将细胞外抗原呈递给CD8（+）效应T细胞（交叉呈递）或CD4（+）T辅助细胞的机制尚未完全解决。我们证明了APC使用不同的内吞机制同时将可溶性抗原引入单独的细胞内区室，这些区室专门用于呈递给CD8（+）或CD4（+）T细胞。具体而言，甘露糖受体提供了一个不同于溶酶体的早期内体区室，其致力于交叉呈递。这些发现意味着抗原不需要细胞内转向进入交叉呈递途径，因为它可以在胞吞作用期间已经进入该途径。
The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8(+) effector T cells (cross-presentation) or to CD4(+) T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation to CD8(+) or CD4(+) T cells. Specifically, the mannose receptor supplied an early endosomal compartment distinct from lysosomes, which was committed to cross-presentation. These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis.