Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells
Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells
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DOI：
10.1210/jc.87.5.2399
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发表时间：
2002-05-01
影响因子：
5.8
通讯作者：
Saji, M
中科院分区：
文献类型：
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作者：
Ringel, MD;Hardy, E;Saji, M
远处转移的发生是甲状腺癌死亡的最重要预测因素。 KiSS-1是最近克隆的人类转移抑制基因，其产物转移蛋白最近被鉴定为新型Gq/11偶联受体（转移蛋白受体）的内源性激动剂。转移蛋白和转移蛋白受体的表达和功能后果尚未在甲状腺癌中进行评估。我们测量了 10 个 FC、13 个乳头状癌 (PC)、2 个良性无功能滤泡腺瘤 (FA) 和 11 个正常甲状腺样本中的转移蛋白和转移蛋白受体 mRNA 水平，并评估了内源表达转移蛋白受体的 ARO 甲状腺癌细胞中转移蛋白激活的信号通路。配对的正常和肿瘤样品可用于 4 个 PC 和 3 个 FC 样品。在 6/11 正常样本、0/2 FA、2/10 FC 和 9/13 PC 样本中检测到肿瘤转移蛋白 mRNA（p
The development of distant metastasis is the most important predictor of death from thyroid cancer. KiSS-1 is a recently cloned human metastasis suppressor gene whose product, metastin, was recently identified as the endogenous agonist for a novel Gq/11 coupled receptor (metastin receptor). The expression and functional consequences of metastin and the metastin receptor have not been evaluated in thyroid cancer. We measured metastin and metastin receptor mRNA levels in 10 FCs and 13 papillary carcinomas (PCs), 2 benign non-functioning follicular adenomas (FAs), and 11 normal thyroid samples, and evaluated the signaling pathways activated by metastin in ARO thyroid cancer cells that express the metastin receptor endogenously. Paired normal and tumor samples were available for 4 PC and 3 FC samples. Metastin mRNA was detected in 6/11 normal samples, and 0/2 FA, 2/10 FC, and 9/13 PC samples (p