FVII, FVIIa, and Downstream Markers of Extrinsic Pathway Activation Differ by EPCR Ser219Gly Variant in Healthy Men
FVII, FVIIa, and Downstream Markers of Extrinsic Pathway Activation Differ by EPCR Ser219Gly Variant in Healthy Men
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DOI：
10.1161/atvbaha.109.191551
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发表时间：
2009-11-01
影响因子：
8.7
通讯作者：
Humphries, Stephen E.
中科院分区：
文献类型：
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作者：
Ireland, Helen A.;Cooper, Jackie A.;Humphries, Stephen E.
EPCR（Ser219Gly），以前显示影响EPCR脱落，对血浆FVII，FVIIa和下游标志物的活化coagulation.Methods和结果进行统计分析，在大约2000健康中年男性（NPHSII）的影响，本研究的目的是确定的效果。Gly等位基因携带者可溶性EPCR水平较高（P
Objective-The purpose of this study was to determine the effect of a variant in EPCR (Ser219Gly), previously shown to affect EPCR shedding, on plasma FVII, FVIIa, and downstream markers of activated coagulation.Methods and Results-Statistical analysis was undertaken in approximate to 2000 healthy middle aged men (NPHSII). Higher soluble EPCR levels were confirmed for Gly allele carriers (P