Intravenous energy and amino acids in the preterm newborn infant: effects on metabolic rate and potential mechanisms of action.
Intravenous energy and amino acids in the preterm newborn infant: effects on metabolic rate and potential mechanisms of action.
复制标题
早产儿的静脉能量和氨基酸：对代谢率和潜在作用机制的影响。
DOI：
10.1016/s0022-3476(87)80357-8
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Finan,D
中科院分区：
文献类型：
--
作者：
Weinstein,MR;Haugen,K;Bauer,JH;Hewitt,J;Finan,D
静脉注射氨基酸和不同量的能量对代谢率的影响进行了研究，并在19个健康的4至6天大的早产儿（30至32周妊娠）的潜在机制进行了检查。这些婴儿被随机分为三组。第1组（n = 6）接受非蛋白质能量38 kcal/kg/d;第2组（n = 5），64 kcal/kg/d;第3组（n = 8），64 kcal/kg/d加1至2 g/kg/d晶体氨基酸。开始输注后36小时，通过间接量热法测量5至6小时的耗氧量（VO2）。同时，收集尿液用于尿去甲肾上腺素排泄，使用液相色谱法和电化学检测法进行测定。用放射免疫法测定血清甲状腺素（T_4）和三碘甲状腺原氨酸（T_3）浓度。第1组的VO2和尿去甲肾上腺素排泄量低于第2组和第3组，但无差异。T4、T3在三组间无差异。VO2和去甲肾上腺素排泄的同时变化与不同的能量摄入无关的年龄支持能量摄入作为交感神经系统的调节剂，这反过来又控制代谢率。静脉注射适量的氨基酸似乎在此过程中不起积极作用，也不改变T3和T4瓣膜。当VO 2随着能量摄入的增加而增加时，T3和T4不受影响，这支持甲状腺激素在饮食诱导的产热中发挥被动作用。
The effects of intravenously administered amino acids and of varying amounts of energy on metabolic rate were studied and potential mechanisms examined in 19 healthy 4- to 6-day-old preterm (30 to 32 weeks gestation) infants. The infants were randomized to three groups. Group 1 (n=6) received nonprotein energy 38 kcal/kg/d; group 2 (n=5), 64 kcal/kg/d; and group 3 (n=8), 64 kcal/kg/d plus 1 to 2 g/kg/d crystalline amino acids. Thirty-six hours after beginning the infusion, oxygen consumption (VO2) was measured by indirect calorimetry for 5 to 6 hours. Simultaneously, urine was collected for urinary norepinephrine excretion, which was determined using liquid chromatography with electrochemical detection. Serum thyroxine (T4) and triiodothyronine (T3) concentrations were determined by radioimmunoassay. Group 1 had lower VO2and urinary norepinephrine excretion than did groups 2 and 3, which did not differ. T4and T3were not different among the three groups. The demonstrated simultaneous changes in VO2and norepinephrine excretion with varying energy intakes independent of age supports energy intake as a modulator of the sympathetic nervous system, which in turn controls metabolic rate. Moderate amounts of intravenously administered amino acids do not appear to play an active role in this process; nor do they alter T3and T4valves. When VO2increased with increasing energy intake, T3and T4were unaffected, supporting a passive role for thyroid hormones in diet-induced thermogenesis.