An Update on the Pathophysiology of Atopic Dermatitis
An Update on the Pathophysiology of Atopic Dermatitis
复制标题
特应性皮炎病理生理学的最新进展
DOI：
10.1016/j.det.2017.02.006
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发表时间：
2017-07-01
影响因子：
2.4
通讯作者：
Czarnowicki, Tali
中科院分区：
文献类型：
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作者：
Malik, Kunal;Heitmiller, Kerry D.;Czarnowicki, Tali
Atopic dermatitis (AD) is increasingly recognized as a complex, inflammatory skin disease involving interplay of multiple elements. This article notes key advances in understanding of immune dysregulation, skin barrier dysfunction, environmental, genetic, and microbial influences orchestrating disease pathogenesis, and the relevance of therapeutic interventions in each area. Accumulating evidence and the discovery of new T-cell subsets has matured AD as a multiple-cytokine-axes-driven disorder, evolved from the widely held belief of it being a biphasic Th1/Th2 disease. These new insights have led to active trials testing multiple, targeted therapeutics with better efficacy and safety-profiles.
