Perfluorooctane sulfonic acid in bib (Trisopterus luscus) and plaice (Pleuronectes platessa) from the Western Scheldt and the Belgian North Sea:: Distribution and biochemical effects
Perfluorooctane sulfonic acid in bib (Trisopterus luscus) and plaice (Pleuronectes platessa) from the Western Scheldt and the Belgian North Sea:: Distribution and biochemical effects
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DOI：
10.1002/etc.5620220320
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发表时间：
2003-03-01
影响因子：
4.1
通讯作者：
De Coen, WM
中科院分区：
文献类型：
--
作者：
Hoff, PT;Van de Vijver, K;De Coen, WM
在比利时北海和西舍尔德河（荷兰）开展了一项生物监测运动，其主要目标是评估全氟辛烷磺酸在不同生物群中的污染和分布。本研究涵盖了对琵琶鱼（Trisopterus luscus）和鲽鱼（Pleuronectes platessa）的研究结果，并包括对一些与应激相关的生化终点的评估。对这两种鱼类的肝脏和肌肉全氟辛烷磺酸浓度的分析提供了证据，表明沿西谢德河存在全氟辛烷磺酸污染梯度，上游地区的全氟辛烷磺酸水平较高，海洋地区的全氟辛烷磺酸污染程度较低。通过测定血清中天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平研究细胞坏死。血清ALT与围区PFOS肝脏浓度呈正相关（r = 0.44, p < 0.05），提示PFOS可能参与了研究区域围区肝损伤的诱导。肝组织总碳水化合物、脂肪和蛋白质含量分析显示，蛋白质含量与PFOS肝脏浓度呈正相关（r = 0.55, p < 0.01）。这是否由于诱导代偿机制，解毒或修复过程尚不清楚。
A biomonitoring campaign was conducted in the Belgian North Sea and in the Western Scheldt (The Netherlands) with the primary goal to assess perfluorooctane sulfonic acid (PFOS) contamination and distribution in different biota. This study covers the results obtained for bib (Trisopterus luscus) and plaice (Pleuronectes platessa) and includes the assessment of some stress-related biochemical endpoints. Analysis of liver and muscle PFOS concentrations of both species provided evidence for the existence of a PFOS pollution gradient along the Western Scheldt with higher levels at the upstream locations and a lower degree of PFOS pollution at the marine locations. Cellular necrosis was studied by measuring aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in the serum. Serum ALT but not serum AST was shown to correlate positively with the PFOS liver concentration in bib (r = 0.44, p < 0.05), indicating that PFOS might contribute to the induction of hepatic damage in bib in the area of study. Analysis of total carbohydrate, lipid, and protein content of bib liver tissue revealed a positive correlation between the protein content and the PFOS liver concentration (r = 0.55, p < 0.01). Whether this is due to induction of compensatory mechanisms, detoxification, or repair processes remains unclear.