Flavivirus Encephalitis: Pathological Aspects of Mouse and Other Animal Models
Flavivirus Encephalitis: Pathological Aspects of Mouse and Other Animal Models
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DOI：
10.1177/0300985810372507
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发表时间：
2010-09-01
影响因子：
2.4
通讯作者：
Sawa, H.
中科院分区：
文献类型：
--
作者：
Kimura, T.;Sasaki, M.;Sawa, H.
脑黄病毒是人类和其他动物重要的节肢动物传播病原体。特别是，最近在新的地理区域出现的西尼罗河病毒和日本脑炎病毒引起了相当大的公共卫生警报和国际关注。在西尼罗河病毒和乙脑病毒感染的实验体内模型中，小鼠和其他实验室啮齿动物是研究最彻底和特征最明确的系统，为了解人类感染过程提供了重要的数据。猕猴也被用作西尼罗河病毒和乙脑病毒感染的模型，主要用于评估疫苗效力，尽管已发表的有限数量的研究涉及病理形态学。这些动物模型表明脑炎的发展与人类疾病有许多相似之处；然而，感染期间发生的组织学事件，特别是外周组织，尚未完全表征。
Encephalitic flaviviruses are important arthropod-borne pathogens of humans and other animals. In particular, the recent emergence of the West Nile virus (WNV) and Japanese encephalitis virus (JEV) in new geographic areas has caused a considerable public health alert and international concern. Among the experimental in vivo models of WNV and JEV infection, mice and other laboratory rodents are the most thoroughly studied and well-characterized systems, having provided data that are important for understanding the infectious process in humans. Macaca monkeys have also been used as a model for WNV and JEV infection, mainly for the evaluation of vaccine efficacy, although a limited number of published studies have addressed pathomorphology. These animal models demonstrate the development of encephalitis with many similarities to the human disease; however, the histological events that occur during infection, especially in peripheral tissues, have not been fully characterized.