Aging, heart rate variability and patterns of autonomic regulation of the heart
Aging, heart rate variability and patterns of autonomic regulation of the heart
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DOI：
10.1016/j.archger.2015.11.011
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发表时间：
2016-03-01
影响因子：
4
通讯作者：
Sobral Sousa, Antonio Carlos
中科院分区：
文献类型：
--
作者：
Almeida-Santos, Marcos Antonio;Barreto-Filho, Jose Augusto;Sobral Sousa, Antonio Carlos
目的：目的探讨年龄、性别和体重指数对心率变异性（HRV）的影响，并比较老年人心率变异性（HRV）的自主神经调节（GAR）和副交感神经流出（PO）的变化。个体年龄从40岁到100岁，功能独立，并具有令人满意的认知功能，定义为自我能力，与面试官（N = 1743）。材料和方法：本研究招募了个人的两种性别，分为五个年龄组。我们对高血压、血脂异常、非胰岛素依赖型糖尿病以及体重指数（BMI）进行了调整。结果：SDNN、SDANN和SDNN指数随年龄和BMI线性下降，女性低于男性（p < 0.001）。rMSSD和pNN 50呈U形模式，男女的最低点在60 - 69岁之间，女性的值高于男性（p < 0.001）。糖尿病患者HRV各变量水平最低（p < 0.001）。高血压和血脂异常对GAR无影响。结论：男女GAR均随年龄增长呈线性下降。女性、糖尿病患者和超重者的死亡率相对较低。PO在两种性别中均呈U形，在第7个十年时达到最低点。在男性和糖尿病患者中也相对较低。高血压和血脂异常对血压无明显影响。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Objectives: To evaluate the effects of aging, gender and body mass index on the heart rate variability (HRV), and to compare the patterns of global autonomic regulation (GAR) and parasympathetic outflow (PO) throughout the aging process.Design, setting and participants: cross-sectional: Large sample of community-based adults and elderly people. Individuals aged from 40 to 100 years, functionally independent and with satisfactory cognitive function defined as the self-capacity to interact with an interviewer (N = 1743).Material and methods: The study enrolled individuals of both genders, stratified into five age-groups. We did adjustments for hypertension, dyslipidemia and non-insulin-dependent diabetes, as well as the body mass index (BMI). All groups undertook long-term electrocardiograms and five time-domain HRV parameters were measured, three (SDNN, SDANN, SDNN-index) reflecting the GAR and two (rMSSD and pNN50) the PO.Results: SDNN, SDANN and SDNN-index decreased linearly with age and BMI, and women had lower values than men (p < 0.001). There was a U-shaped pattern of rMSSD and pNN50, with the nadir between 60 and 69 years for both genders, and women had higher values than men (p < 0.001). The lowest levels of all HRV variables were found in diabetics (p < 0.001). There was no influence of hypertension or dyslipidemia.Conclusions: The GAR decreased linearly with the age in both genders. It is comparatively lower in women, diabetics and overweight individuals. The PO presented the U-shape in both genders with the nadir at the 7th decade. It was also comparatively lower in men and diabetics. Hypertension and dyslipidemia imparted no significant influence. (C) 2015 Elsevier Ireland Ltd. All rights reserved.