Concentrations of free carnosine (a putative membrane-protective antioxidant) in human muscle biopsies and rat muscles
Concentrations of free carnosine (a putative membrane-protective antioxidant) in human muscle biopsies and rat muscles
复制标题
DOI：
10.1016/s0167-4943(99)00020-5
复制
发表时间：
1999-09-01
影响因子：
4
通讯作者：
Kunze, K
中科院分区：
文献类型：
--
作者：
Stuerenburg, HJ;Kunze, K
肌肽可能对骨骼肌的收缩能力有功能作用，以及膜保护和抗氧化作用。我们测定了神经肌肉疾病患者骨骼肌中的组织游离肌肽浓度，以及不同年龄大鼠的骨骼肌和心肌中的肌肽浓度。用逐步多元线性回归模型分析年龄、性别和诊断类别对神经肌肉疾病患者游离肌肽水平的影响。患者的年龄是肌肽浓度的显著负预测因子(R=-0.40，P<；0.05)。大鼠骨骼肌游离肌肽含量与年龄呈显著负相关(雄性r=-0.49，P<0.05；雌性r=-0.56，P<0.05)。在逐步回归模型中，只有诊断类别肌萎缩侧索硬化症(ALS)与对照组相比是显著的负预测因素，这一点经Wilcoxon符号等级检验证实(P<；0.05)。我们的结论是，与年龄相关的肌肉质量、力量和功能的下降与假定的膜保护抗氧化剂肌肽的组织浓度下降有关。此外，我们发现肌肽在肌萎缩侧索硬化症中的组织浓度降低。肌肽含量的减少可能是由进行性的去神经过程引起的。(C)1999爱思唯尔爱尔兰科学有限公司。保留所有权利。
Carnosine has possible functional effects on skeletal muscle contractility, along with membrane-protective, antioxidant effects. We determined tissue free carnosine concentrations in skeletal muscles from patients with neuromuscular diseases and in skeletal and heart muscles from rats of various ages. The effects of age, gender and diagnostic category on free carnosine levels in patients with neuromuscular diseases were analyzed by a stepwise multiple linear regression model. The age of the patients emerged as a significant negative predictor of carnosine concentrations (R = -0.40, P < 0.05). Free carnosine concentrations in rat skeletal muscles also showed a significant negative correlation with the ages of the rats (male rats: R = -0.49, P < 0.05; female rats: R = -0.56, P < 0.05). Only the diagnostic category amyotrophic lateral sclerosis (ALS) emerged as a significant negative predictor compared to the control group in the stepwise regression model, this was confirmed by Wilcoxon Signed Rank Test (P < 0.05). We conclude that the age-related decline in muscle mass, strength and function is associated with decreased tissue concentrations of the putative membrane-protective antioxidant carnosine. In addition we found decreased carnosine tissue concentrations in ALS. The reduction in carnosine content might be caused by progressive denervation processes. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.