SYNAPTIC POTENTIALS AND EFFECTS OF AMINO-ACID ANTAGONISTS IN THE AUDITORY-CORTEX
SYNAPTIC POTENTIALS AND EFFECTS OF AMINO-ACID ANTAGONISTS IN THE AUDITORY-CORTEX
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DOI：
10.1016/0361-9230(92)90039-z
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发表时间：
1992-03-01
影响因子：
3.8
通讯作者：
ASHE, JH
中科院分区：
文献类型：
--
作者：
COX, CL;METHERATE, R;ASHE, JH
离体豚鼠和大鼠听皮层神经元接受传入信息的复杂突触模式。对灰质或白色物质的单一刺激脉冲可以产生多达四种突触反应;一种早期EPSP，随后依次是早期IPSP和晚期EPSP。晚IPSP。成对脉冲刺激和药理学研究表明，早期IPSP可以改变通过早期EPSP发生的信息传递。这四种突触反应中的每一种在估计的逆转电位上都不同。并且每一种对药理学试剂的拮抗作用的敏感性不同。使君子酸/红藻氨酸受体拮抗剂DNQX（6，7-二硝基喹啉-2，3-二酮）可阻断早期EPSP，而NMDA受体拮抗剂APV（D-2-氨基-5-磷酸戊酸）可阻断晚期EPSP。GABA-a受体拮抗剂荷包牡丹碱可阻断早期IPSP，GABA-b受体拮抗剂2-OH saclofen或phaclofen可阻断晚期IPSP。呈现的刺激列车，即使在相对较低的强度，可以产生一个持久的APV敏感的膜去极化。还讨论了这些突触电位在听皮层功能和可塑性中的可能作用。
Neurons of in vitro guinea pig and rat auditory cortex receive a complex synaptic pattern of afferent information. As many as four synaptic responses to a single-stimulus pulse to the gray or white matter can occur; an early-EPSP followed, sequentially, by an early-IPSP, late-EPSP. and late-IPSP. Paired pulse stimulation and pharmacological studies show that the early-IPSP can modify information transmission that occurs by way of the early-EPSP. Each of these four synaptic responses differed in estimated reversal potential. and each was differentially sensitive to antagonism by pharmacological agents. DNQX (6,7-dinitroquinoxaline-2,3-dione), a quisqualate/kainate receptor antagonist, blocked the early-EPSP, and the late-EPSP was blocked by the NMDA receptor antagonist APV (D-2-amino-5-phosphonovalerate). The early-IPSP was blocked by the GABA-a receptor antagonist bicuculline, and the late-IPSP by the GABA-b receptor antagonists 2-OH saclofen or phaclofen. Presentation of stimulus trains, even at relatively low intensities, could produce a long-lasting APV-sensitive membrane depolarization. Also discussed is the possible role of these synaptic potentials in auditory cortical function and plasticity.