Local landmark-based mapping of human auditory cortex
Local landmark-based mapping of human auditory cortex
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DOI：
10.1016/j.neuroimage.2004.04.013
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发表时间：
2004-08-01
期刊：
影响因子：
5.7
通讯作者：
Woods, DL
中科院分区：
文献类型：
--
作者：
Kang, XJ;Bertrand, O;Woods, DL
哺乳动物的感觉皮层在功能上被划分为专门用于不同处理操作的皮质区域。理论上，对不同受试者的功能和解剖图像进行平均，可以揭示感觉区域的平均解剖结构和平均功能组织。然而，这种平均过程必须克服至少两个障碍：(1)不同受试者的皮质感觉区域的相对位置和大小不同，因此跨受试者平均会引入空间涂抹；(2)皮层区域的相对位置和大小在两个半球之间存在差异，这使得很难比较两个半球之间的激活或将两个半球之间的激活结合起来。这些困难对于像听觉皮层这样的小皮质区域尤其严重。在全脑平均过程中，听觉皮层外结构的大小和形状的差异引入了听觉皮层位置和方向的相当大的主体间差异。在这里，我们将这些全局方法与基于局部解剖地标的局部地标方法（LLMs）进行了比较。与全局方法绘制的图相比，LLMs绘制的听觉皮层解剖图具有更清晰的脑回和脑沟结构，并绘制出分辨率更高的功能图。这些结果表明，在研究听觉皮层组织的细节方面，llm比全局映射程序具有显著的优势。(C) 2004爱思唯尔公司版权所有。
Mammalian sensory cortex is functionally partitioned into cortical fields that are specialized for different processing operations. In theory, averaging functional and anatomical images across subjects can reveal both the average anatomy and the mean functional organization of sensory regions. However, this averaging process must overcome at least two obstacles: (1) the relative locations and sizes of cortical sensory areas vary in different subjects so that across-subject averaging introduces spatial smearing; (2) the relative locations and sizes of cortical areas vary between hemispheres, making it difficult to compare activations between hemispheres or to combine activations across hemispheres. These difficulties are particularly acute for small cortical regions such as auditory cortex.In whole-brain averaging procedures, considerable intersubject variance in the location and orientation of auditory cortex is introduced by variance of the size and shape of structures outside auditory cortex. Here, we compared these global methods with local landmark-based methods (LLMs) that use warping based on local anatomical landmarks. In comparison to maps made with global methods, LLMs produced anatomical maps of auditory cortex with clearer gyral and sulcal structure, and produce functional maps with improved resolution. These results suggest that LLMs have significant advantages over global mapping procedures in studying the details of auditory cortex organization. (C) 2004 Elsevier Inc. All rights reserved.