Regulation of Treg Cell Metabolism and Function in Non-Lymphoid Tissues.
Regulation of Treg Cell Metabolism and Function in Non-Lymphoid Tissues.
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DOI：
10.3389/fimmu.2022.909705
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
调节性T细胞（Regulator T cells，Tcells）在维持免疫耐受和调节针对病原体和肿瘤的免疫应答中起着关键作用。细胞代谢的重编程已被确定为连接微环境线索和信号网络以影响组织THBE的稳态和功能的关键过程。在适应各种非淋巴组织中，THBE协调局部免疫信号和信号网络以重新连接细胞代谢程序以维持其抑制功能。改变的Treg代谢进而形成Treg活化和功能。鉴于对免疫代谢的深入理解，操纵全身代谢物已成为一种有吸引力的策略，旨在调节组织THBE的代谢和功能，并改善免疫相关疾病的治疗。在这篇综述中，我们总结了关键的免疫信号和代谢程序参与的组织TCLs的调节，审查TCLs在各种非淋巴组织的分化和功能的机制，并讨论了治疗干预的组织TCLs的代谢调节剂治疗自身免疫性疾病和癌症。
Regulator T cells (Tregs) play pivotal roles in maintaining immune tolerance and regulating immune responses against pathogens and tumors. Reprogramming of cellular metabolism has been determined as a crucial process that connects microenvironmental cues and signaling networks to influence homeostasis and function of tissue Tregs. In adaptation to a variety of non-lymphoid tissues, Tregs coordinate local immune signals and signaling networks to rewire cellular metabolic programs to sustain their suppressive function. Altered Treg metabolism in turn shapes Treg activation and function. In light of the advanced understanding of immunometabolism, manipulation of systemic metabolites has been emerging as an attractive strategy aiming to modulate metabolism and function of tissue Tregs and improve the treatment of immune-related diseases. In this review, we summarize key immune signals and metabolic programs involved in the regulation of tissue Tregs, review the mechanisms underlying the differentiation and function of Tregs in various non-lymphoid tissues, and discuss therapeutic intervention of metabolic modulators of tissue Tregs for the treatment of autoimmune diseases and cancer.
影响因子：
5.4
作者：
Kim, James I.;Sonawane, Samsher B.;Lee, Major K.;Lee, Seoung-Hoon;Duff, Patrick E.;Moore, Daniel J.;O'Connor, Matthew R.;Lian, Moh-Moh;Deng, Shaoping;Choi, Yongwon;Yeh, Heidi;Caton, Andrew J.;Markmann, James F.
通讯作者：
Markmann, James F.