The role of stromal-derived factor-1--CXCR7 axis in development and cancer.
The role of stromal-derived factor-1--CXCR7 axis in development and cancer.
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DOI：
10.1016/j.ejphar.2009.04.071
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发表时间：
2009-12-25
影响因子：
5
通讯作者：
Ratajczak MZ
中科院分区：
文献类型：
--
作者：
Maksym RB;Tarnowski M;Grymula K;Tarnowska J;Wysoczynski M;Liu R;Czerny B;Ratajczak J;Kucia M;Ratajczak MZ
癌症转移是导致治疗失败的主要临床问题。越来越多的证据表明，转移性癌细胞采用了几种参与正常干细胞发育运输的机制。基质衍生因子-1（SDF-1）是一种重要的α-趋化因子，与G蛋白偶联的七跨膜跨膜CXCR 4结合。SDF-1-CXCR 4轴调节正常和恶性细胞的运输。SDF-1是包括造血干/祖细胞在内的多种细胞的重要化学引诱物。多年来，人们认为CXCR 4是SDF-1的唯一受体。然而，最近的一些报道提供了证据表明，SDF-1还结合到另一种称为CXCR 7的七跨膜跨膜受体，与另一种称为干扰素诱导T细胞化学引诱物（I-TAC）的趋化因子家族成员共享该受体。因此，随着CXCR 7被鉴定为SDF-1的新受体，SDF-1-CXCR 4轴在调节几种生物过程中的作用变得更加复杂。本文综述了SDF-1与CXCR 7相互作用的生物学意义，CXCR 7可能作为一种诱饵或信号受体，这取决于细胞类型。越来越多的证据表明，CXCR 7参与肿瘤发生的几个方面，并可能成为新的抗转移和抗癌药物的重要靶点。
Cancer metastasis is a major clinical problem that contributes to unsuccessful therapy. Augmenting evidence indicates that metastasizing cancer cells employ several mechanisms that are involved in developmental trafficking of normal stem cells. Stromal-derived factor-1 (SDF-1) is an important α-chemokine that binds to the G-protein-coupled seven-transmembrane span CXCR4. The SDF-1-CXCR4 axis regulates trafficking of normal and malignant cells. SDF-1 is an important chemoattractant for a variety of cells including hematopoietic stem/progenitor cells. For many years, it was believed that CXCR4 was the only receptor for SDF-1. However, several reports recently provided evidence that SDF-1 also binds to another seven-transmembrane span receptor called CXCR7, sharing this receptor with another chemokine family member called Interferon-inducible T-cell chemoattractant (I-TAC). Thus, with CXCR7 identified as a new receptor for SDF-1, the role of the SDF-1-CXCR4 axis in regulating several biological processes becomes more complex. Based on the available literature, this review addresses the biological significance of SDF-1’s interaction with CXCR7, which may act as a kind of decoy or signaling receptor depending on cell type. Augmenting evidence suggests that CXCR7 is involved in several aspects of tumorogenesis and could become an important target for new anti-metastatic and anti-cancer drugs.
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影响因子：
56.9
作者：
Feng, Y;Broder, CC;Berger, EA
通讯作者：
Berger, EA
影响因子：
45.3
作者：
Devine, SM;Flomenberg, N;DiPersio, JF
通讯作者：
DiPersio, JF
影响因子：
5.2
作者：
Guo, Y;Hangoc, G;Broxmeyer, HE
通讯作者：
Broxmeyer, HE
DOI：
10.1073/pnas.252339399
发表时间：
2002-12-10
影响因子：
11.1
作者：
David, NB;Sapède, D;Ghysen, A
通讯作者：
Ghysen, A
DOI：
10.1084/jem.187.12.2009
发表时间：
1998-06-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cole KE;Strick CA;Paradis TJ;Ogborne KT;Loetscher M;Gladue RP;Lin W;Boyd JG;Moser B;Wood DE;Sahagan BG;Neote K
通讯作者：
Neote K