The role of myocardial fibrillar collagen in ventricular remodeling and function
The role of myocardial fibrillar collagen in ventricular remodeling and function
复制标题
DOI：
10.1054/jcaf.2002.129260
复制
发表时间：
2002-12-01
影响因子：
6
通讯作者：
Brower, GL
中科院分区：
文献类型：
--
作者：
Janicki, JS;Brower, GL
心肌细胞外基质（ECM）包围并连接心肌细胞、肌原纤维、肌纤维和冠状动脉微循环。由于纤维胶原的高拉伸强度及其与心肌功能成分的密切联系，间质胶原的改变可显著影响心腔的大小和形状以及心室功能。通常，继发于压力超负荷的间质胶原蛋白浓度的增加导致心肌和心室变得更硬。相比之下，胶原蛋白浓度的降低，其特征在于纤维状胶原蛋白的破坏和消失，导致左心室明显扩张，其明显更具顺应性。然而，心肌ECM改变对收缩功能的影响仍有待确定。本文简要总结了心肌细胞外基质改变的结构和功能后果，并讨论了我们的知识差距和未来的研究方向。
The myocardial extracellular matrix (ECM) surrounds and interconnects cardiac myocytes, myofibrils, muscle fibers, and the coronary microcirculation. Because of the high tensile strength of fibrillar collagen and its close association with the functioning components of the myocardium, alterations in interstitial collagen can significantly influence the size and shape of the cardiac chambers as well as ventricular function. Typically, an increase in interstitial collagen concentration secondary to pressure overload results in both the myocardium and the ventricle becoming stiffer. In contrast, a reduction in collagen concentration characterized by a disruption and disappearance of fibrillar collagen leads to a markedly dilated left ventricle that is significantly more compliant. However, the effects of myocardial ECM alterations on systolic function remain to be determined. This article provides a brief summary of the structural and functional consequences of alterations to the myocardial ECM and discusses gaps in our knowledge and future research directions.