Characterization of tachykinin receptors in urinary bladder from guinea pig.
Characterization of tachykinin receptors in urinary bladder from guinea pig.
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豚鼠膀胱中速激肽受体的表征。
DOI：
10.1254/jjp.54.241
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
I. Takayanagi
中科院分区：
文献类型：
--
作者：
M. Shinkai;I. Takayanagi
研究了豚鼠逼尿肌条对P物质（SP）、神经激肽A （NKA）、tyr -神经激肽B （Tyr-NKB）、senktide （NK3受体选择性激动剂）和SP甲酯（SPOMe， NK1受体选择性激动剂）的收缩反应。除senktide外，所有药物均呈浓度相关收缩，其效价大小顺序为：SPOMe > SP > NKA >或等于Tyr-NKB。NK1受体与SPOMe脱敏后，效力等级为NKA大于等于tyr1 - nkb大于SP大于SPOMe。豚鼠逼尿肌条中同时存在NK1和NK2受体。
The contractile responses to substance P (SP), neurokinin A (NKA), Tyro-neurokinin B (Tyr-NKB), senktide (NK3 receptor selective agonist) and SP methyl ester (SPOMe, NK1 receptor selective agonist) were investigated in detrusor strips from guinea pigs. Except for senktide, all drugs induced a concentration-related contraction with the following rank order of potency: SPOMe greater than SP greater than NKA greater than or equal to Tyr-NKB. After desensitization of NK1 receptors with SPOMe, the rank order of potency was NKA greater than or equal to Tyr-NKB greater than SP greater than SPOMe. Both NK1 and NK2 receptors exist in the detrusor strip from guinea pigs.